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Alzheimer's disease therapeutics: new approaches to an ageing problem

journal contribution
posted on 2023-05-17, 02:28 authored by David SmallDavid Small, Losic, D, Martin, LL, Turner, BJ, Freidhuber, A, Aguilar, MI
Abnormal proteinaceous deposits are found in the brain of patients with many different neurodegenerative diseases. In many of these diseases, the production of the deposits is probably associated with disease pathogenesis. In Alzheimer's disease (AD), the amyloid protein (Aâ), is produced by the action of enzymes known as secretases, which cleave the â-amyloid protein precursor. Aâ is secreted from cells in the brain, after which it oligomerizes and is deposited in the extracellular compartment of the brain to form amyloid plaques and amyloid angiopathy. Targeting the production of Aâ and its aggregation is now a key strategy in the development of novel therapeutic agents for the treatment of AD. This review examines the potential of immunization strategies, cholesterol-lowering drugs, protease inhibitors and nicotinic drugs for the treatment of AD

History

Publication title

I U B M B Life: (International Union of Biochemistry and Molecular Biology)

Volume

56

Issue

4

Pagination

203-208

ISSN

1521-6543

Department/School

Menzies Institute for Medical Research

Publisher

Taylor & Francis Inc

Place of publication

325 Chestnut St, Suite 800, Philadelphia, USA, Pa, 19106

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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