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Alzheimer's disease therapeutics: new approaches to an ageing problem
Citation
Small, DH and Losic, D and Martin, LL and Turner, BJ and Freidhuber, A and Aguilar, MI, Alzheimer's disease therapeutics: new approaches to an ageing problem, I U B M B Life: (International Union of Biochemistry and Molecular Biology), 56, (4) pp. 203-208. ISSN 1521-6543 (2004) [Refereed Article]
DOI: doi:10.1080/15216540410001709211
Abstract
Abnormal proteinaceous deposits are found in the brain of patients with many different neurodegenerative diseases. In many of these diseases, the production of the deposits is probably associated with disease pathogenesis. In Alzheimer's disease (AD), the amyloid protein (Aâ), is produced by the action of enzymes known as secretases, which cleave the â-amyloid protein precursor. Aâ is secreted from cells in the brain, after which it oligomerizes and is deposited in the extracellular compartment of the brain to form amyloid plaques and amyloid angiopathy. Targeting the production of Aâ and its aggregation is now a key strategy in the development of novel therapeutic agents for the treatment of AD. This review examines the potential of immunization strategies, cholesterol-lowering drugs, protease inhibitors and nicotinic drugs for the treatment of AD
Item Details
Item Type: | Refereed Article |
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Keywords: | Alzheimer's disease; Amyloid; Cholesterol; Dementia; Immunotherapy; Nicotine; Secretas |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Neurosciences |
Research Field: | Neurosciences not elsewhere classified |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Small, DH (Professor David Small) |
ID Code: | 63318 |
Year Published: | 2004 |
Web of Science® Times Cited: | 5 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2010-04-28 |
Last Modified: | 2010-09-16 |
Downloads: | 0 |
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