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Do acetylcholinesterase inhibitors boost synaptic scaling in Alzheimer's disease?


Small, DH, Do acetylcholinesterase inhibitors boost synaptic scaling in Alzheimer's disease?, Trends in Neurosciences, 27, (5) pp. 245-249. ISSN 0166-2236 (2004) [Refereed Article]

DOI: doi:10.1016/j.tins.2004.03.006


Studies on neural networks indicate that the pattern of amnesia that occurs in Alzheimer's disease (AD) can be reproduced by synaptic loss, but only when this loss is accompanied by synaptic scaling, a homeostatic mechanism that maintains the level of excitatory input on postsynaptic neurons. It is suggested that increased cholinergic activity during the early stages of AD contributes to synaptic scaling and that acetylcholinesterase inhibitors improve cognition in AD patients by boosting this mechanism.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Neurosciences not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Small, DH (Professor David Small)
ID Code:63317
Year Published:2004
Web of Science® Times Cited:27
Deposited By:Menzies Institute for Medical Research
Deposited On:2010-04-28
Last Modified:2010-09-16

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