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Acetycholinesterase is increased in mouse neuronal and astrocyte cultures after treatment with β-amyloid peptides
journal contribution
posted on 2023-05-17, 02:28 authored by Saez-Valero, J, Fodero, LR, White, AR, Barrow, CJ, David SmallDavid SmallThe cellular origin of the acetylcholinesterase (AChE) associated with amyloid plaques in the Alzheimer's disease (AD) brain is unknown. In this study we report that amyloid â-peptides (Aâ) increased AChE levels in both neuronal and astrocytic primary cultures, supporting the possibility that both neurons and glia may make a direct contribution to the pool of AChE seen around amyloid deposits in the AD brain.
History
Publication title
Brain Research: International Multidisciplinary Journal Devoted to Fundamental Research in The Brain SciencesVolume
965Issue
1-2Pagination
283-286ISSN
0006-8993Department/School
Menzies Institute for Medical ResearchPublisher
Elsevier Science BvPlace of publication
Po Box 211, Amsterdam, Netherlands, 1000 AeRepository Status
- Restricted