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Acetycholinesterase is increased in mouse neuronal and astrocyte cultures after treatment with β-amyloid peptides

Citation

Saez-Valero, J and Fodero, LR and White, AR and Barrow, CJ and Small, DH, Acetycholinesterase is increased in mouse neuronal and astrocyte cultures after treatment with β-amyloid peptides, Brain Research: International Multidisciplinary Journal Devoted to Fundamental Research in The Brain Sciences, 965, (1-2) pp. 283-286. ISSN 0006-8993 (2003) [Refereed Article]

DOI: doi:10.1016/S0006-8993(02)04159-8

Abstract

The cellular origin of the acetylcholinesterase (AChE) associated with amyloid plaques in the Alzheimer's disease (AD) brain is unknown. In this study we report that amyloid -peptides (A) increased AChE levels in both neuronal and astrocytic primary cultures, supporting the possibility that both neurons and glia may make a direct contribution to the pool of AChE seen around amyloid deposits in the AD brain.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Neurosciences not elsewhere classified
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Neurodegenerative Disorders Related to Ageing
Author:Small, DH (Professor David Small)
ID Code:63308
Year Published:2003
Web of Science® Times Cited:16
Deposited By:Menzies Institute for Medical Research
Deposited On:2010-04-28
Last Modified:2010-09-16
Downloads:0

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