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Acetycholinesterase is increased in mouse neuronal and astrocyte cultures after treatment with β-amyloid peptides
Citation
Saez-Valero, J and Fodero, LR and White, AR and Barrow, CJ and Small, DH, Acetycholinesterase is increased in mouse neuronal and astrocyte cultures after treatment with β-amyloid peptides, Brain Research: International Multidisciplinary Journal Devoted to Fundamental Research in The Brain Sciences, 965, (1-2) pp. 283-286. ISSN 0006-8993 (2003) [Refereed Article]
DOI: doi:10.1016/S0006-8993(02)04159-8
Abstract
The cellular origin of the acetylcholinesterase (AChE) associated with amyloid plaques in the Alzheimer's disease (AD) brain is unknown. In this study we report that amyloid â-peptides (Aâ) increased AChE levels in both neuronal and astrocytic primary cultures, supporting the possibility that both neurons and glia may make a direct contribution to the pool of AChE seen around amyloid deposits in the AD brain.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Research Division: | Medical and Health Sciences |
| Research Group: | Neurosciences |
| Research Field: | Neurosciences not elsewhere classified |
| Objective Division: | Health |
| Objective Group: | Clinical Health (Organs, Diseases and Abnormal Conditions) |
| Objective Field: | Neurodegenerative Disorders Related to Ageing |
| Author: | Small, DH (Professor David Small) |
| ID Code: | 63308 |
| Year Published: | 2003 |
| Web of Science® Times Cited: | 16 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2010-04-28 |
| Last Modified: | 2010-09-16 |
| Downloads: | 0 |
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