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Assessment of thrombin generation
journal contribution
posted on 2023-05-22, 23:35 authored by Adams, MJThrombin plays a central role in haemostasis through both procoagulant and anticoagulant functions. Although measurement of thrombin generation in the laboratory has been possible for many years, recent advances in understanding a wider scope of physiological roles of thrombin as well as improvements in technology have resulted in methods that are less technically demanding and more reproducible. Consequently, thrombin-generation assays continue to be evaluated as a potentially useful laboratory method for determining haemostatic abnormalities, including both bleeding and thrombotic conditions, and for monitoring anticoagulant therapy. Despite these advances limitations still remain, including lack of standardisation between methods and the reporting of few large, well-designed studies, although this is likely to change in the next few years.
History
Publication title
European HaematologyVolume
4Pagination
16-18Department/School
School of Health SciencesPlace of publication
LondonRights statement
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