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Design considerations for pulsed-flow comprehensive two-dimensional GC: Dynamic flow model approach


Harvey, PM and Shellie, RA and Haddad, PR, Design considerations for pulsed-flow comprehensive two-dimensional GC: Dynamic flow model approach, Journal of Chromatographic Science, 48, (4) pp. 245-250. ISSN 0021-9665 (2010) [Refereed Article]

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Copyright © 2010 Preston Publications

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DOI: doi:10.1093/chromsci/48.4.245


A dynamic flow model, which maps carrier gas pressures and carrier gas flow rates through the first dimension separation column, the modulator sample loop, and the second dimension separation column(s) in a pulsed-flow modulation comprehensive two-dimensional gas chromatography (PFM-GC×GC) system is described. The dynamic flow model assists design of a PFM-GC×GC modulator and leads to rapid determination of pneumatic conditions, timing parameters, and the dimensions of the separation columns and connecting tubing used to construct the PFM-GC×GC system. Three significant innovations are introduced in this manuscript, which were all uncovered by using the dynamic flow model. A symmetric flow path modulator improves baseline stability, appropriate selection of the flow restrictors in the first dimension column assembly provides a generally more stable and robust system, and these restrictors increase the modulation period flexibility of the PFM-GC×GC system. The flexibility of a PFM-GC×GC system resulting from these innovations is illustrated using the same modulation interface to analyze Special Antarctic Blend (SAB) diesel using 3 s and 9 s modulation periods.

Item Details

Item Type:Refereed Article
Research Division:Chemical Sciences
Research Group:Analytical chemistry
Research Field:Separation science
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the chemical sciences
UTAS Author:Harvey, PM (Mr Paul Harvey)
UTAS Author:Shellie, RA (Associate Professor Robert Shellie)
UTAS Author:Haddad, PR (Professor Paul Haddad)
ID Code:63186
Year Published:2010
Funding Support:Australian Research Council (DP0771893)
Web of Science® Times Cited:12
Deposited By:Austn Centre for Research in Separation Science
Deposited On:2010-04-19
Last Modified:2015-01-28

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