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Design considerations for pulsed-flow comprehensive two-dimensional GC: Dynamic flow model approach
journal contribution
posted on 2023-05-17, 02:24 authored by Harvey, PM, Robert ShellieRobert Shellie, Paul HaddadPaul HaddadA dynamic flow model, which maps carrier gas pressures and carrier gas flow rates through the first dimension separation column, the modulator sample loop, and the second dimension separation column(s) in a pulsed-flow modulation comprehensive two-dimensional gas chromatography (PFM-GC×GC) system is described. The dynamic flow model assists design of a PFM-GC×GC modulator and leads to rapid determination of pneumatic conditions, timing parameters, and the dimensions of the separation columns and connecting tubing used to construct the PFM-GC×GC system. Three significant innovations are introduced in this manuscript, which were all uncovered by using the dynamic flow model. A symmetric flow path modulator improves baseline stability, appropriate selection of the flow restrictors in the first dimension column assembly provides a generally more stable and robust system, and these restrictors increase the modulation period flexibility of the PFM-GC×GC system. The flexibility of a PFM-GC×GC system resulting from these innovations is illustrated using the same modulation interface to analyze Special Antarctic Blend (SAB) diesel using 3 s and 9 s modulation periods.
Funding
Australian Research Council
History
Publication title
Journal of Chromatographic ScienceVolume
48Issue
4Pagination
245-250ISSN
0021-9665Department/School
School of Natural SciencesPublisher
Preston Publications IncPlace of publication
7800 Merrimac Ave Po Box 48312, Niles, USA, Il, 60648Rights statement
Copyright © 2010 Preston PublicationsRepository Status
- Restricted