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Mosaic Genomes of the Six Major Primate Lentivirus Lineages Revealed by Phylogenetic Analyses
Citation
Salemi, M and De Oliveira, T and Courgnaud, V and Moulton, V and Holland, BR and Cassol, S and Switzer, WM and Vandamme, AM, Mosaic Genomes of the Six Major Primate Lentivirus Lineages Revealed by Phylogenetic Analyses, Journal of Virology, 77, (13) pp. 7202-7213. ISSN 0022-538X (2003) [Refereed Article]
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Copyright Statement
Copyright © 2003, American Society for Microbiology.
Official URL: http://journals.asm.org/misc/ASM_Author_Statement....
DOI: doi:10.1128/JVI.77.13.7202-7213.2003
Abstract
To clarify the origin and evolution of the primate lentiviruses (PLVs), which include human immunodeficiency
virus types 1 and 2 as well as their simian relatives, simian immunodeficiency viruses (SIVs), isolated
from several host species, we investigated the phylogenetic relationships among the six supposedly nonrecombinant
PLV lineages for which the full genome sequences are available. Employing bootscanning as an
exploratory tool, we located several regions in the PLV genome that seem to have uncertain or conflicting
phylogenetic histories. Phylogeny reconstruction based on distance and maximum-likelihood algorithms followed
by a number of statistical tests confirms the existence of at least five putative recombinant fragments in
the PLV genome with different clustering patterns. Split decomposition analysis also shows that phylogenetic
relationships among PLVs may be better represented by network-based graphs, such as the ones produced by
SplitsTree. Our findings not only imply that the six so-called pure PLV lineages have in fact mosaic genomes
but also make more unlikely the hypothesis of cospeciation of SIVs and their simian hosts.
Item Details
Item Type: | Refereed Article |
---|---|
Research Division: | Biological Sciences |
Research Group: | Evolutionary biology |
Research Field: | Phylogeny and comparative analysis |
Objective Division: | Expanding Knowledge |
Objective Group: | Expanding knowledge |
Objective Field: | Expanding knowledge in the biological sciences |
UTAS Author: | Holland, BR (Professor Barbara Holland) |
ID Code: | 63076 |
Year Published: | 2003 |
Web of Science® Times Cited: | 31 |
Deposited By: | Mathematics |
Deposited On: | 2010-04-13 |
Last Modified: | 2010-04-29 |
Downloads: | 401 View Download Statistics |
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