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Molecular and physiologic actions of insulin related to production of nitric oxide in vascular endothelium


Vincent, MA and Montagnani, M and Quon, MJ, Molecular and physiologic actions of insulin related to production of nitric oxide in vascular endothelium, Current Diabetes Reports, 3, (4) pp. 279-288. ISSN 1534-4827 (2003) [Refereed Article]

DOI: doi:10.1007/s11892-003-0018-9


Insulin has important vascular actions that regulate blood flow, in addition to its classical actions to coordinate glucose homeostasis. Insulin-stimulated production of nitric oxide in vascular endothelium results in capillary recruitment and vasodilation that diverts and increases blood flow to skeletal muscle and consequently increases glucose disposal. Thus, vascular actions of insulin may be essential for coupling hemodynamic and metabolic homeostasis. A complete biochemical signaling pathway linking the insulin receptor to activation of endothelial nitric oxide synthase in vascular endothelium has recently been elucidated. Moreover, the time course and dose response for capillary recruitment in response to physiologic concentrations of insulin parallels that of insulin-mediated glucose uptake in vivo. Taken together, these observations suggest a molecular mechanism that may help to explain how insulin resistance contributes to cardiovascular components of the metabolic syndrome and vascular complications of diabetes. Copyright © 2003 by Current Science Inc.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Endocrinology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Vincent, MA (Dr Michelle Keske)
ID Code:62833
Year Published:2003
Deposited By:Menzies Institute for Medical Research
Deposited On:2010-03-24
Last Modified:2011-09-30

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