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Molecular and physiologic actions of insulin related to production of nitric oxide in vascular endothelium

journal contribution
posted on 2023-05-17, 02:16 authored by Michelle Keske, Montagnani, M, Quon, MJ
Insulin has important vascular actions that regulate blood flow, in addition to its classical actions to coordinate glucose homeostasis. Insulin-stimulated production of nitric oxide in vascular endothelium results in capillary recruitment and vasodilation that diverts and increases blood flow to skeletal muscle and consequently increases glucose disposal. Thus, vascular actions of insulin may be essential for coupling hemodynamic and metabolic homeostasis. A complete biochemical signaling pathway linking the insulin receptor to activation of endothelial nitric oxide synthase in vascular endothelium has recently been elucidated. Moreover, the time course and dose response for capillary recruitment in response to physiologic concentrations of insulin parallels that of insulin-mediated glucose uptake in vivo. Taken together, these observations suggest a molecular mechanism that may help to explain how insulin resistance contributes to cardiovascular components of the metabolic syndrome and vascular complications of diabetes. Copyright © 2003 by Current Science Inc.

History

Publication title

Current Diabetes Reports

Issue

4

Pagination

279-288

ISSN

1534-4827

Department/School

Menzies Institute for Medical Research

Publisher

Current Medicine Group LLC

Place of publication

United States

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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