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Validation and advantages of FAWSETS perfusion measurements in skeletal muscle
journal contribution
posted on 2023-05-17, 02:15 authored by Marro, KI, Hyyti, OM, Michelle Keske, Kushmerick, MJThis work discusses the strengths, limitations and validity of a novel arterial spin labeling technique when used specifically to measure perfusion in limb skeletal muscle. The technique, flow-driven arterial water stimulation with elimination of tissue signal (FAWSETS), offers several advantages over existing arterial spin labeling techniques. The primary goal of this study was to determine the perfusion signal response to changes in net hind limb flow that were independently verifiable. The range of perfusate flow was relevant to skeletal muscle during mild to moderate exercise. Localized, single voxel measurements were acquired from a 5 mm-thick slice in the isolated perfused rat hind limb at variable net flow rates. The results show that the perfusion signal is linearly proportional to net hind limb flow with a correlation coefficient of 0.974 (p =0.0013). FAWSETS is especially well suited for studies of skeletal muscle perfusion, where it eliminates the need to compensate for magnetization transfer and arterial transit time effects. A conceptual discussion of the basic principles underlying these advantages is presented.
History
Publication title
N M R in Biomedicine: (Nuclear Magnetic Resonance)Volume
18Issue
4Pagination
226-234ISSN
0952-3480Department/School
Menzies Institute for Medical ResearchPublisher
John Wiley & Sons LtdPlace of publication
The Atrium, Southern Gate, Chichester, England, W Sussex, Po19 8SqRepository Status
- Restricted