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Validation and advantages of FAWSETS perfusion measurements in skeletal muscle

Citation

Marro, KI and Hyyti, OM and Vincent, MA and Kushmerick, MJ, Validation and advantages of FAWSETS perfusion measurements in skeletal muscle , N M R in Biomedicine: (Nuclear Magnetic Resonance), 18, (4) pp. 226-234. ISSN 0952-3480 (2005) [Refereed Article]

DOI: doi:10.1002/nbm.950

Abstract

This work discusses the strengths, limitations and validity of a novel arterial spin labeling technique when used specifically to measure perfusion in limb skeletal muscle. The technique, flow-driven arterial water stimulation with elimination of tissue signal (FAWSETS), offers several advantages over existing arterial spin labeling techniques. The primary goal of this study was to determine the perfusion signal response to changes in net hind limb flow that were independently verifiable. The range of perfusate flow was relevant to skeletal muscle during mild to moderate exercise. Localized, single voxel measurements were acquired from a 5 mm-thick slice in the isolated perfused rat hind limb at variable net flow rates. The results show that the perfusion signal is linearly proportional to net hind limb flow with a correlation coefficient of 0.974 (p =0.0013). FAWSETS is especially well suited for studies of skeletal muscle perfusion, where it eliminates the need to compensate for magnetization transfer and arterial transit time effects. A conceptual discussion of the basic principles underlying these advantages is presented.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Endocrinology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Diabetes
Author:Vincent, MA (Dr Michelle Keske)
ID Code:62771
Year Published:2005
Web of Science® Times Cited:8
Deposited By:Menzies Institute for Medical Research
Deposited On:2010-03-22
Last Modified:2010-05-03
Downloads:0

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