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Serum parathyroid hormone predicts time to fall independent of vitamin D status in a frail elderly population


Sambrook, P and Chen, JS and March, L and Cameron, ID and Cumming, RJ and Lord, SR and Zochling, JM and Sitoh, YY and Lau, TC and Schwartz, J and Seibel, MJ, Serum parathyroid hormone predicts time to fall independent of vitamin D status in a frail elderly population, Journal of Clinical Endocrinology and Metabolism, 89, (4) pp. 1572-1576. ISSN 0021-972X (2004) [Refereed Article]

DOI: doi:10.1210/jc.2003-031782


Very frail older people constitute an increasing proportion of ageing populations and often have vitamin D deficiency. Falls are frequent in this population and have usually been associated with vitamin D deficiency. In this prospective study we measured serum 25-hydroxyvitamin D (25OHD), serum PTH, and falls in 637 ambulatory subjects living in institutional aged care facilities (intermediate-care hostels or nursing homes). The study sample comprised 121 men (mean age, 82.1 yr) and 516 women (mean age, 86.7 yr). Two hundred and seventy-four subjects fell one or more times over a mean duration of follow-up of 10.2 months. Vitamin D deficiency, defined as a serum 25OHD level below 39 nmol/liter was present in 73.6%. Baseline serum 25OHD and PTH were significantly associated with falls in univariate analyses. In multivariate analyses that also corrected for balance and health status, PTH remained a significant predictor of falls independent of 25OHD. Serum PTH is a predictor of time to first fall in the frail elderly independent of vitamin D status and measures of general health.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Rheumatology and arthritis
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Zochling, JM (Dr Jane Zochling)
ID Code:62641
Year Published:2004
Web of Science® Times Cited:80
Deposited By:Menzies Institute for Medical Research
Deposited On:2010-03-15
Last Modified:2010-05-04

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