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Identification of seven new prostate cancer susceptibility loci through a genome-wide association study


Eeles, RA and Kote-Jarai, Z and Amin Al Olama, A and Giles, GG and Guy, M and Severi, G and Muir, K and Hopper, JL and Henderson, BE and Haiman, CA and Schleutker, J and Hamdy, FC and Neal, DE and Donovan, JL and Stanford, JL and Ostrander, EA and Ingles, SA and John, EM and Thibodeau, SN and Schaid, D and Park, JY and Spurdle, A and Clements, J and Dickinson, JL and Maier, C and Vogel, W and Dork, T and Rebbeck, TR and Cooney, KA and Cannon-Albright, L and Chappuis, PO and Hutter, P and Zeegers, M and Kaneva, R and Zhang, HW and Lu, YJ and Foulkes, WD and English, DR and Leongamornlert, DA and Tymrakiewicz, M and Morrison, J and Ardern-Jones, AT and Hall, AL and O'Brien, LT and Wilkinson, RA and Saunders, EJ and Page, EC and Sawyer, EJ and Edwards, SM and Dearnaley, DP and Horwich, A and Huddart, RA and Khoo, VS and Parker, CC and Van As, N and Woodhouse, CJ and Thompson, A and Christmas, T and Ogden, C and Cooper, CS and Southey, MC and Lophatananon, A and Liu, JF and Kolonel, LN and Le Marchand, L and Wahlfors, T and Tammela, TL and Auvinen, A and Lewis, SJ and Cox, A and Fitzgerald, LM and Koopmeiners, JS and Karyadi, DM and Kwon, EM and Stern, MC and Corral, R and Joshi, AD and Shahabi, A and McDonnell, SK and Sellers, TA and Pow-Sang, J and Chambers, S and Aitken, J and Gardiner, RA and Batra, J and Kedda, MA and Lose, F and Polanowski, AM and Patterson, B and Serth, J and Meyer, A and Luedeke, M and Stefflova, K and Ray, AM and Lange, EM and Farnham, J and Khan, H and Slavov, C and Mitkova, A and Cao, G and Easton, DF and The UK ProtecT Study, The PRACTICAL Consortium , Identification of seven new prostate cancer susceptibility loci through a genome-wide association study, Nature Genetics, 41, (10) pp. 1116-1121. ISSN 1061-4036 (2009) [Refereed Article]

DOI: doi:10.1038/ng.450


Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed countries. To identify common PrCa susceptibility alleles, we previously conducted a genome-wide association study in which 541,129 SNPs were genotyped in 1 1,854 PrCa cases with clinically detected disease and in 1 1,894 controls. We have now extended the study to evaluate promising associations in a second stage in which we genotyped 43,671 1 SNPs in 3,650 PrCa cases and 3,940 controls and in a third stage involving an additional 16,229 cases and 14,821 controls from 21 studies. In addition to replicating previous associations, we identified seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11 and 22 (with P = 1 1.6 ื 10−8 to P = 2.7 ื 10−33).

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Oncology and carcinogenesis
Research Field:Cancer genetics
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Dickinson, JL (Professor Joanne Dickinson)
UTAS Author:Fitzgerald, LM (Dr Liesel Fitzgerald)
UTAS Author:Polanowski, AM (Ms Andrea Polanowski)
UTAS Author:Patterson, B (Dr Briony Patterson)
UTAS Author:The UK ProtecT Study, The PRACTICAL Consortium (Professor Simon Foote)
ID Code:61859
Year Published:2009
Web of Science® Times Cited:333
Deposited By:Menzies Institute for Medical Research
Deposited On:2010-03-08
Last Modified:2011-08-24

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