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Identification of seven new prostate cancer susceptibility loci through a genome-wide association study
journal contribution
posted on 2023-05-17, 01:49 authored by Eeles, RA, Kote-Jarai, Z, Amin Al Olama, A, Giles, GG, Guy, M, Severi, G, Muir, K, Hopper, JL, Henderson, BE, Haiman, CA, Schleutker, J, Hamdy, FC, Neal, DE, Donovan, JL, Stanford, JL, Ostrander, EA, Ingles, SA, John, EM, Thibodeau, SN, Schaid, D, Park, JY, Spurdle, A, Clements, J, Joanne DickinsonJoanne Dickinson, Maier, C, Vogel, W, Dork, T, Rebbeck, TR, Cooney, KA, Cannon-Albright, L, Chappuis, PO, Hutter, P, Zeegers, M, Kaneva, R, Zhang, HW, Lu, YJ, Foulkes, WD, English, DR, Leongamornlert, DA, Tymrakiewicz, M, Morrison, J, Ardern-Jones, AT, Hall, AL, O'Brien, LT, Wilkinson, RA, Saunders, EJ, Page, EC, Sawyer, EJ, Edwards, SM, Dearnaley, DP, Horwich, A, Huddart, RA, Khoo, VS, Parker, CC, Van As, N, Woodhouse, CJ, Thompson, A, Christmas, T, Ogden, C, Cooper, CS, Southey, MC, Lophatananon, A, Liu, JF, Kolonel, LN, Le Marchand, L, Wahlfors, T, Tammela, TL, Auvinen, A, Lewis, SJ, Cox, A, Liesel FitzgeraldLiesel Fitzgerald, Koopmeiners, JS, Karyadi, DM, Kwon, EM, Stern, MC, Corral, R, Joshi, AD, Shahabi, A, McDonnell, SK, Sellers, TA, Pow-Sang, J, Chambers, S, Aitken, J, Gardiner, RA, Batra, J, Kedda, MA, Lose, F, Polanowski, AM, Patterson, B, Serth, J, Meyer, A, Luedeke, M, Stefflova, K, Ray, AM, Lange, EM, Farnham, J, Khan, H, Slavov, C, Mitkova, A, Cao, G, Easton, DF, Simon James FooteSimon James FooteProstate cancer (PrCa) is the most frequently diagnosed cancer in males in developed countries. To identify common PrCa susceptibility alleles, we previously conducted a genome-wide association study in which 541,129 SNPs were genotyped in 1 1,854 PrCa cases with clinically detected disease and in 1 1,894 controls. We have now extended the study to evaluate promising associations in a second stage in which we genotyped 43,671 1 SNPs in 3,650 PrCa cases and 3,940 controls and in a third stage involving an additional 16,229 cases and 14,821 controls from 21 studies. In addition to replicating previous associations, we identified seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11 and 22 (with P = 1 1.6 × 10−8 to P = 2.7 × 10−33).
History
Publication title
Nature GeneticsVolume
41Issue
10Pagination
1116-1121ISSN
1061-4036Department/School
Menzies Institute for Medical ResearchPublisher
Nature Publishing GroupPlace of publication
345 Park Ave South, New York, USA, Ny, 10010-1707Repository Status
- Restricted
