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Chlorinative stress: An under appreciated mediator of neurodegeneration?


Yap, YW and Whiteman, M and Cheung, NS, Chlorinative stress: An under appreciated mediator of neurodegeneration?, Cellular Signalling, 19, (2) pp. 219-228. ISSN 0898-6568 (2007) [Refereed Article]

DOI: doi:10.1016/j.cellsig.2006.06.013


Oxidative stress has been implicated as playing a role in neurodegenerative disorders, such as ischemic stroke, Alzheimer's, Huntington's, and Parkinson's disease. Persuasive evidences have shown that microglial-mediated oxidative stress contributes significantly to cell loss and accompanying cognitive decline characteristic of the diseases. Based on the facts that (i) levels of catalytically active myeloperoxidase are elevated in diseased brains and (ii) myeloperoxidase polymorphism is associated with the risk of developing neurodegenerative disorders, HOCl as a major oxidant produced by activated phagocytes in the presence of myeloperoxidase is therefore suggested to be involved in neurodegeneration. Its association with neurodegeneration is further showed by elevated level of 3-chlorotyrosine (bio-marker of HOCl in vivo) in affected brain regions as well as HOCl scavenging ability of neuroprotectants, desferrioxamine and uric acid. In this review, we will summary the current understanding concerning the association of HOCl and neuronal cell death where production of HOCl will lead to further formation of reactive nitrogen and oxygen species. In addition, HOCl also causes tissue destruction and cellular damage leading cell death.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Cellular nervous system
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Cheung, NS (Dr Nam Cheung)
ID Code:61686
Year Published:2007
Web of Science® Times Cited:445
Deposited By:Menzies Institute for Medical Research
Deposited On:2010-03-05
Last Modified:2010-05-03

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