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Cytoplasmic Domain of the â-Amyloid Protein Precursor of Alzheimer's Disease: Function, Regulation of Proteolysis, and Implications for Drug Development

Citation

Kerr, ML and Small, DH, Cytoplasmic Domain of the â-Amyloid Protein Precursor of Alzheimer's Disease: Function, Regulation of Proteolysis, and Implications for Drug Development, Journal of Neuroscience Research, 80, (2) pp. 151-159. ISSN 0360-4012 (2005) [Refereed Article]


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DOI: doi:10.1002/jnr.20408

Abstract

The -amyloid protein precursor (APP) has been extensively studied for its role in amyloid production and the pathogenesis of Alzheimer's disease (AD). However, little is known about the normal function of APP and its biological interactions. In this Mini-Review, the role of the cytoplasmic domain of APP in APP trafficking and proteolysis is described. These studies suggest that proteins that bind to the cytoplasmic domain may be important targets for drug development in AD.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Neurosciences not elsewhere classified
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Neurodegenerative Disorders Related to Ageing
Author:Small, DH (Professor David Small)
ID Code:61447
Year Published:2005
Web of Science® Times Cited:25
Deposited By:Menzies Institute for Medical Research
Deposited On:2010-03-03
Last Modified:2010-07-13
Downloads:0

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