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Immunocytochemical localization of non-NMDA ionotropic excitatory amino acid receptor subunits in human neocortex

journal contribution
posted on 2023-05-16, 09:58 authored by James VickersJames Vickers, Huntley, GW, Hof, PR, Bederson, J, DeFelipe, J, Morrison, JH
The distribution of immunocytochemically localized subunits that comprise ionotropic non-NMDA excitatory amino acid receptors was examined in human frontal, parietal and temporal association neocortex. AMPA/kainate receptor subunits were identified using a monoclonal antibody (3A11) that recognizes an epitope common to GluR2 and GluR4 [GluR2(4)], as well as polyclonal antisera that recognize GluR2 and GluR3 (GluR2/3). Kainate receptor subunits were identified using a monoclonal antibody (4F5) that recognizes an epitope common to GluR5/6/7. For all three antibodies used, labeling was observed in a large number of neurons throughout the human association neocortex with the highest immunoreactivity present in pyramidal-like neurons, a cellular pattern largely similar to that observed in the monkey neocortex. These data demonstrate the cellular localization patterns for some non-NMDA receptor subunits in human neocortex, details upon which further studies on the roles of these subunits in human neurological diseases can be based. © 1995.

History

Publication title

Brain Research

Volume

671

Pagination

175-180

ISSN

0006-8993

Department/School

Tasmanian School of Medicine

Publisher

Elsevier Science Bv

Place of publication

The Netherlands

Repository Status

  • Restricted

Socio-economic Objectives

Other health not elsewhere classified

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