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Immunocytochemical localization of non-NMDA ionotropic excitatory amino acid receptor subunits in human neocortex

Citation

Vickers, JC and Huntley, GW and Hof, PR and Bederson, J and DeFelipe, J and Morrison, JH, Immunocytochemical localization of non-NMDA ionotropic excitatory amino acid receptor subunits in human neocortex, Brain Research, 671, (1) pp. 175-180. ISSN 0006-8993 (1995) [Refereed Article]

DOI: doi:10.1016/0006-8993(94)01372-O

Abstract

The distribution of immunocytochemically localized subunits that comprise ionotropic non-NMDA excitatory amino acid receptors was examined in human frontal, parietal and temporal association neocortex. AMPA/kainate receptor subunits were identified using a monoclonal antibody (3A11) that recognizes an epitope common to GluR2 and GluR4 [GluR2(4)], as well as polyclonal antisera that recognize GluR2 and GluR3 (GluR2/3). Kainate receptor subunits were identified using a monoclonal antibody (4F5) that recognizes an epitope common to GluR5/6/7. For all three antibodies used, labeling was observed in a large number of neurons throughout the human association neocortex with the highest immunoreactivity present in pyramidal-like neurons, a cellular pattern largely similar to that observed in the monkey neocortex. These data demonstrate the cellular localization patterns for some non-NMDA receptor subunits in human neocortex, details upon which further studies on the roles of these subunits in human neurological diseases can be based. © 1995.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Central Nervous System
Objective Division:Health
Objective Group:Other Health
Objective Field:Health not elsewhere classified
Author:Vickers, JC (Professor James Vickers)
ID Code:6141
Year Published:1995
Web of Science® Times Cited:22
Deposited By:Pathology
Deposited On:1995-08-01
Last Modified:2011-08-25
Downloads:0

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