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Acetylcholinesterase inhibitors for the treatment of dementia in Alzheimer's disease: do we need new inhibitors?
Citation
Small, DH, Acetylcholinesterase inhibitors for the treatment of dementia in Alzheimer's disease: do we need new inhibitors?, Expert Opinion on Emerging Drugs, 10, (4) pp. 817-825. ISSN 1744-7623 (2005) [Refereed Article]
DOI: doi:10.1517/14728214.10.4.817
Abstract
Acetylcholinesterase inhibitors (AChEIs) have been shown to produce a small, but significant, improvement in cognition in patients with Alzheimer's disease. However, not all patients respond equally, and cognitive benefit may be of limited duration. Although new AChEIs continue to be developed, more recent studies have been aimed at developing inhibitors that have additional actions separate from AChE inhibition. Importantly, new treatments that target the underlying pathogenic mechanism of Alzheimer's disease (statins, secretase inhibitors, vaccination) may eventually emerge. These new treatments could make AChEI therapy less relevant for treatment of Alzheimer's disease.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Research Division: | Medical and Health Sciences |
| Research Group: | Neurosciences |
| Research Field: | Neurosciences not elsewhere classified |
| Objective Division: | Health |
| Objective Group: | Clinical Health (Organs, Diseases and Abnormal Conditions) |
| Objective Field: | Neurodegenerative Disorders Related to Ageing |
| Author: | Small, DH (Professor David Small) |
| ID Code: | 61391 |
| Year Published: | 2005 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2010-03-03 |
| Last Modified: | 2011-10-04 |
| Downloads: | 0 |
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