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Neural Network Dysfunction in Alzheimer's Disease: A Drug Development Perspective

Citation

Small, DH, Neural Network Dysfunction in Alzheimer's Disease: A Drug Development Perspective, Drug News and Perspectives: The International Drug Newsmagazine, 20, (9) pp. 557-563. ISSN 0214-0934 (2007) [Refereed Article]

DOI: doi:10.1358/dnp.2007.20.9.1162245

Abstract

Over the last few years, a major focus of Alzheimer's disease research has been to understand the mechanisms by which build-up of the -amyloid protein (A) in the brain leads to chronic neurodegeneration and eventual cell death. It is increasingly recognized that cell death is not a major cause of dementia. Indeed, recent studies suggest that A causes neuritic dystrophy and interferes with mechanisms of synaptic plasticity such as long-term potentiation. There are also a number of well-described homeostatic mechanisms in the brain that help to maintain signal strength as a consequence of lowered synaptic input, which may occur as a consequence of neuritic dystrophy. This review examines mechanisms of synaptic scaling in the brain and explores prospects for future drug development based on a neural network perspective.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Neurosciences not elsewhere classified
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Neurodegenerative Disorders Related to Ageing
Author:Small, DH (Professor David Small)
ID Code:61388
Year Published:2007
Web of Science® Times Cited:4
Deposited By:Menzies Institute for Medical Research
Deposited On:2010-03-03
Last Modified:2010-09-16
Downloads:0

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