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Neural Network Dysfunction in Alzheimer's Disease: A Drug Development Perspective
Over the last few years, a major focus of Alzheimer's disease research has been to understand the mechanisms by which build-up of the â-amyloid protein (Aâ) in the brain leads to chronic neurodegeneration and eventual cell death. It is increasingly recognized that cell death is not a major cause of dementia. Indeed, recent studies suggest that Aâ causes neuritic dystrophy and interferes with mechanisms of synaptic plasticity such as long-term potentiation. There are also a number of well-described homeostatic mechanisms in the brain that help to maintain signal strength as a consequence of lowered synaptic input, which may occur as a consequence of neuritic dystrophy. This review examines mechanisms of synaptic scaling in the brain and explores prospects for future drug development based on a neural network perspective.
History
Publication title
Drug News and Perspectives: The International Drug NewsmagazineVolume
20Issue
9Pagination
557-563ISSN
0214-0934Department/School
Menzies Institute for Medical ResearchPublisher
Prous SciencePlace of publication
Sa, Po Box 540, Provenza 388, Barcelona, Spain, 08025Repository Status
- Restricted