eCite Digital Repository

Developmental roles for Homer: more than just a pretty scaffold

Citation

Foa, LC and Gasperini, RJ, Developmental roles for Homer: more than just a pretty scaffold, Journal of Neurochemistry, 108, (1) pp. 1-10. ISSN 0022-3042 (2009) [Refereed Article]


Preview
PDF
Restricted - Request a copy
324Kb
  

Copyright Statement

The definitive published version is available online at: http://interscience.wiley.com

Official URL: http://interscience.wiley.com

DOI: doi:10.1111/j.1471-4159.2008.05726.x

Abstract

Homer proteins are best known as scaffold proteins at the post-synaptic density where they facilitate synaptic signalling and are thought to be required for learning and memory. Evidence implicating Homer proteins in the development of the nervous system is also steadily accumulating. Homer is highly conserved and is expressed at key developmental time points in the nervous system of several species. Homer regulates intracellular calcium homeostasis, clustering and trafficking of receptors and proteins at the cytosolic surface of the plasma membrane, transcription and translation, and cytoskeletal organization. Each of these functions has obvious potential to regulate neuronal development, and indeed Homer is implicated in several pathologies associated with the developing nervous system. Current data justify more critical experimental approaches to the role of Homer in the developing nervous system and related neurological disorders. Keywords: Homer, mental retardation, mGluR, neuronal development, synaptic signalling. J. Neurochem. (2009) 108, 110.

Item Details

Item Type:Refereed Article
Keywords:Homer mental retardation mGluR neuronal development synaptic signalling
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Cellular Nervous System
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Foa, LC (Professor Lisa Foa)
Author:Gasperini, RJ (Dr Rob Gasperini)
ID Code:61378
Year Published:2009
Web of Science® Times Cited:24
Deposited By:Medicine
Deposited On:2010-03-03
Last Modified:2010-06-24
Downloads:1 View Download Statistics

Repository Staff Only: item control page