eCite Digital Repository

Intraperikaryal neurofilamentous accumulations in a subset of retinal ganglion cells in aged mice that express a human neurofilament gene

Citation

Vickers, JC and Lazzarini, RA and Riederer, BM and Morrison, JH, Intraperikaryal neurofilamentous accumulations in a subset of retinal ganglion cells in aged mice that express a human neurofilament gene, Experimental Neurology, 136, (2) pp. 266-269. ISSN 0014-4886 (1995) [Refereed Article]

DOI: doi:10.1006/exnr.1995.1104

Abstract

Neurofilamentous changes in select groups of neurons are associated with the degenerative changes of many human age-related neurodegenerative diseases. To examine the possible effects of aging on the neuronal cytoskeleton containing human proteins, the retinas of transgenic mice expressing the gene for the human middle-sized neurofilament triplet were investigated at 3 or 12 months of age. Transgenic mice developed tangle-like neurofilamentous accumulations in a subset of retinal ganglion cells at 12 months of age. These neurofilamentous accumulations, which also involved endogenous neurofilament proteins, were present in the perikarya and proximal processes of large ganglion cells and were predominantly located in peripheral retina. The presence of the human protein may thus confer vulnerability of the cytoskeleton to age-related alterations in this specific retinal cell type and may serve as a model for similar cellular changes associated with Alzheimer's disease and glaucoma.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Central Nervous System
Objective Division:Health
Objective Group:Other Health
Objective Field:Health not elsewhere classified
Author:Vickers, JC (Professor James Vickers)
ID Code:6137
Year Published:1995
Web of Science® Times Cited:12
Deposited By:Pathology
Deposited On:1995-08-01
Last Modified:2011-08-25
Downloads:0

Repository Staff Only: item control page