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Effects of aldosterone on forearm vasculature in treated chronic heart failure


Gunaruwan, P and Schmitt, M and Sharman, JE and Lee, L and Struthers, A and Frenneaux, M, Effects of aldosterone on forearm vasculature in treated chronic heart failure, The American Journal of Cardiology, 95, (3) pp. 412-414. ISSN 0002-9149 (2005) [Refereed Article]

DOI: doi:10.1016/j.amjcard.2004.09.047


The nongenomic effects of aldosterone in disease states associated with endothelial dysfunction may differ from those in healthy subjects. The effects of locally infused aldosterone on the forearm blood flow and volume were studied in optimally treated patients with chronic heart failure (CHF). At baseline and after incremental intrabrachial aldosterone, forearm blood flow was assessed using conventional strain gauge plethysmography, and forearm venous volume was assessed by radionuclide plethysmography. Constriction of the resistance vasculature of the forearm without significant effect on forearm venous capacitance was demonstrated in response to aldosterone in patients treated for CHF.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Cardiology (incl. cardiovascular diseases)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Sharman, JE (Professor James Sharman)
ID Code:61336
Year Published:2005
Web of Science® Times Cited:17
Deposited By:Menzies Institute for Medical Research
Deposited On:2010-03-02
Last Modified:2010-05-03

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