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Evidence for abnormal left ventricular structure and function in normotensive individuals with familial hyperaldosteronism type 1


Stowasser, M and Sharman, JE and Leano, R and Gordon, RD and Ward, G and Cowley, D and Marwick, TM, Evidence for abnormal left ventricular structure and function in normotensive individuals with familial hyperaldosteronism type 1, Journal of Clinical Endocrinology and Metabolism, 90, (9) pp. 5070-5076. ISSN 0021-972X (2005) [Refereed Article]

DOI: doi:10.1210/jc.2005-0681


Objectives: To explore whether aldosterone excess can induce adverse cardiovascular effects independently of effects on blood pressure (BP), we sought evidence of disturbed cardiovascular structure or function in normotensive individuals with primary aldosteronism. Methods: Eight normotensive subjects with genetically proven familial hyperaldosteronism type I (FH-I) were compared with 24 age- and sex-matched normotensive controls in terms of BP, biochemical parameters, pulse wave velocity, and echocardiographic characteristics. Results: Subjects with FH-I demonstrated higher serum aldosterone levels and aldosterone/renin ratios than controls, as expected. Despite having similar 24-h ambulatory BPs, subjects with FH-I demonstrated evidence of concentric remodeling with greater septal (mean SD, 9.4 1.1 vs. 7.9 0.9 mm; P < 0.001), posterior wall (9.2 1.7 vs. 7.7 1.0 mm; P < 0.01), and relative wall (0.29 0.03 vs. 0.24 0.02; P < 0.001) thicknesses, and lower mitral early peak velocities (0.74 0.10 vs. 0.90 0.16 m/sec; P < 0.05), ratios of early to late peak diastolic transmitral flow velocity (1.56 0.24 vs. 2.06 0.41; P < 0.01), and myocardial early peak velocities (8.3 1.8 vs. 10.3 2.6 cm/sec; P < 0.05). There were no significant differences in pulse wave velocity or left ventricular ejection fraction, long axis strain rate, peak systolic strain, cyclic variation of integrated backscatter, or posterior wall calibrated integrated backscatter. Conclusions: Aldosterone excess is associated with increased left ventricular wall thicknesses and reduced diastolic function, even in the absence of hypertension.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Cardiology (incl. cardiovascular diseases)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Sharman, JE (Professor James Sharman)
ID Code:61320
Year Published:2005
Web of Science® Times Cited:164
Deposited By:Menzies Institute for Medical Research
Deposited On:2010-03-02
Last Modified:2010-05-04

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