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Murine neonatal melanocytes exhibit a heightened proliferative response to ultraviolet radiation and migrate to the epidermal basal layer
Citation
Walker, GJ and Kimlin, MG and Hacker, E and Ravishankar, S and Muller, HK and Beermann, F and Hayward, NK, Murine neonatal melanocytes exhibit a heightened proliferative response to ultraviolet radiation and migrate to the epidermal basal layer, Journal of Investigative Dermatology , 129, (1) pp. 184-192. ISSN 0022-202X (2009) [Refereed Article]
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Copyright © 2009 Nature Publishing Group, a division of Macmillan Publishers Limited.
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Abstract
Melanocytes respond to UVR not only by producing melanin, but also by proliferating. This is essentially a
protective response. We have studied the melanocyte proliferative response after a single UVR exposure to
neonatal mice. At 3 days post-UVR in wild-type neonates we observed a marked melanocyte activation not seen
in adults. Melanocytes migrated to the epidermal basal layer, their numbers peaking at 3–5 days after UVR then
diminishing. They appeared to emanate from the hair follicle, migrating to the epidermis via the outer root
sheath. In melanoma-prone mice with melanocyte-specific overexpression of HrasG12V, basal layer melanocytes
were increased in size and dendricity compared to UVR-treated wild-type mice. Melanocytes in mice carrying a
pRb pathway cell-cycle defect (oncogenic Cdk4R24C) did not show an enhanced response to UVR such as those
carrying HrasG12V. The exquisite sensitivity to UVR-induced proliferation and migration that characterizes
neonatal mouse melanocytes may partly explain the utility of this form of exposure for inducing melanoma in
mice that carry oncogenic mutations.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Research Division: | Medical and Health Sciences |
| Research Group: | Oncology and Carcinogenesis |
| Research Field: | Cancer Cell Biology |
| Objective Division: | Health |
| Objective Group: | Clinical Health (Organs, Diseases and Abnormal Conditions) |
| Objective Field: | Cancer and Related Disorders |
| UTAS Author: | Muller, HK (Professor Konrad Muller) |
| ID Code: | 61317 |
| Year Published: | 2009 |
| Web of Science® Times Cited: | 39 |
| Deposited By: | School of Medicine |
| Deposited On: | 2010-03-02 |
| Last Modified: | 2012-03-05 |
| Downloads: | 0 |
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