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The effect of exercise on large artery hemodynamics in healthy young men


Sharman, JE and McEniery, CM and Campbell, RI and Coombes, JS and Wilkinson, IB and Cockcroft, JR, The effect of exercise on large artery hemodynamics in healthy young men, European Journal of Clinical Investigation, 35, (12) pp. 738-744. ISSN 0014-2972 (2005) [Refereed Article]

DOI: doi:10.1111/j.1365-2362.2005.01578.x


Background: Brachial blood pressure predicts cardiovascular outcome at rest and during exercise. However, because of pulse pressure amplification, there is a marked difference between brachial pressure and central (aortic) pressure. Although central pressure is likely to have greater clinical importance, very little data exist regarding the central haemodynamic response to exercise. The aim of the present study was to determine the central and peripheral haemodynamic response to incremental aerobic exercise. Materials and methods: Twelve healthy men aged 31 1 years (mean SEM) exercised at 50%, 60%, 70% and 80% of their maximal heart rate (HRmax) on a bicycle ergometer. Central blood pressure and estimated aortic pulse wave velocity, assessed by timing of the reflected wave (TR), were obtained noninvasively using pulse wave analysis. Pulse pressure amplification was defined as the ratio of peripheral to central pulse pressure and, to assess the influence of wave reflection on amplification, the ratio of peripheral pulse pressure to nonaugmented central pulse pressure (PPP: CDBP-P1) was also calculated. Results: During exercise, there was a significant, intensity-related, increase in mean arterial pressure and heart rate (P < 0.001). There was also a significant increase in pulse pressure amplification and in PPP: CDBP-P1 (P < 0.001), but both were independent of exercise intensity. Estimated aortic pulse wave velocity increased during exercise (P < 0.001), indicating increased aortic stiffness. There was also a positive association between aortic pulse wave velocity and mean arterial pressure (r = 0.54; P < 0.001). Conclusions: Exercise significantly increases pulse pressure amplification and estimated aortic stiffness.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Cardiology (incl. cardiovascular diseases)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Sharman, JE (Professor James Sharman)
ID Code:61299
Year Published:2005
Web of Science® Times Cited:67
Deposited By:Menzies Institute for Medical Research
Deposited On:2010-03-02
Last Modified:2010-05-03

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