eCite Digital Repository
Identification of a new noradrenaline induced gene in the rat heart by differential messenger-RNA display
Citation
Venkataraman, R and Presser, JL and Vaillancourt, RE and West, AK, Identification of a new noradrenaline induced gene in the rat heart by differential messenger-RNA display, Cardiovascular Research, 29, (4) pp. 490-494. ISSN 0008-6363 (1995) [Refereed Article]
DOI: doi:10.1016/0008-6363(96)88524-5
Abstract
Objective: Noradrenaline treatment of animals results in postnatal hypertrophy of the heart. This process requires many qualitative and quantitative changes in gene expression; however, the identities of the key regulatory genes which modulate the process are not known. The aim of this study was to investigate whether a recently developed technique, differential display, could provide a new route to the identification and characterisation of these critical genes. Methods: The technique of differential display was modified for use on cardiac RNA samples and the expression of clones identified by this approach was characterised by northern analysis. Results: Differential display was successfully adapted to the study of noradrenaline induced cardiac gene expression. A previously unsuspected gene was identified, the expression of which appears to be strongly modified during the onset of this process. Conclusions: Differential display offers the potential to identify and clone many of the genes critically important in regulation of growth of the mammalian heart.
Item Details
Item Type: | Refereed Article |
---|---|
Research Division: | Biological Sciences |
Research Group: | Biochemistry and Cell Biology |
Research Field: | Cell Metabolism |
Objective Division: | Expanding Knowledge |
Objective Group: | Expanding Knowledge |
Objective Field: | Expanding Knowledge in the Environmental Sciences |
UTAS Author: | Venkataraman, R (Mr Rajan Venkataraman) |
UTAS Author: | Presser, JL (Ms Jennifer Louise Presser) |
UTAS Author: | Vaillancourt, RE (Professor Rene Vaillancourt) |
UTAS Author: | West, AK (Professor Adrian West) |
ID Code: | 6126 |
Year Published: | 1995 |
Web of Science® Times Cited: | 4 |
Deposited By: | Biochemistry |
Deposited On: | 1995-08-01 |
Last Modified: | 2011-08-25 |
Downloads: | 0 |
Repository Staff Only: item control page