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Nitrogen excretion by the sheep abomasal parasite Teladorsagia circumcincta
Citation
Simpson, HV and Muhamad, N and Walker, LR and Simcock, DC and Brown, SC and Pedley, KC, Nitrogen excretion by the sheep abomasal parasite Teladorsagia circumcincta, Experimental Parasitology, 123, (1) pp. 17-23. ISSN 0014-4894 (2009) [Refereed Article]
DOI: doi:10.1016/j.exppara.2009.05.003
Abstract
Excretion of nitrogenous substances by Teladorsagia circumcincta was investigated during incubation of L3 in phosphate buffer for up to 30 h and adult worms for 4-6 h. Ammonia was the main excretory product, with about 20% urea. For the first 4-6 h, ammonia excretion by L3 was temperature dependent, directly proportional to the number of larvae, but independent of the pH or strength of the phosphate buffer. Later, ammonia excretion slowed markedly in L3 and adults and reversed to net uptake in L3 by 30 h. An initial external ammonia concentration of 600 μM did not alter the pattern or magnitude of excretion. Re-uptake of ammonia did not occur at extremes of pH or low buffer strength and was slightly reduced at the highest external concentrations. Ammonium transporters and enzymes of glutamate metabolism, including glutamate dehydrogenase, glutamine synthetase and possibly glutamate synthase, are worthy of further investigation as anthelmintic targets. © 2009 Elsevier Inc. All rights reserved.
Item Details
Item Type: | Refereed Article |
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Research Division: | Agricultural, Veterinary and Food Sciences |
Research Group: | Veterinary sciences |
Research Field: | Veterinary parasitology |
Objective Division: | Animal Production and Animal Primary Products |
Objective Group: | Livestock raising |
Objective Field: | Sheep for wool |
UTAS Author: | Brown, SC (Dr Simon Brown) |
ID Code: | 61143 |
Year Published: | 2009 |
Web of Science® Times Cited: | 9 |
Deposited By: | Health Sciences A |
Deposited On: | 2010-02-26 |
Last Modified: | 2010-10-06 |
Downloads: | 0 |
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