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Mannose-binding lectin status is associated with risk of major infection following myeloablative sibling allogeneic hematopoietic stem cell transplantation

Citation

Mullighan, CG and Heatley, SL and Dean, MM and Doherty, KV, Mannose-binding lectin status is associated with risk of major infection following myeloablative sibling allogeneic hematopoietic stem cell transplantation, Blood, 112, (5) pp. 2120-2128. ISSN 0006-4971 (2008) [Refereed Article]

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Copyright Statement

Copyright 2008 The American Society of Hematology

DOI: doi:10.1182/blood-2007-07-100222

Abstract

Mannose-binding lectin (MBL) is a mediator of innate immunity that influences the risk of infection in a range of clinical settings. We previously reported associations between MBL2 genotype and infection in a retrospective study of myeloablative allogeneic hematopoietic stem cell transplantation (allo-HCT). However, other studies have been inconclusive, and the role of MBL in reducedintensity conditioning (RIC) transplantation is unknown. Here we report a prospective study examining MBL2 genotype, MBL levels, and risk of major infection following HLA-matched sibling myeloablative (n=83) and RIC (n=59) HCT. Baseline MBL levels were higher in recipients than donors (P < .001), and recipient MBL levels increased during the peritransplantation period (P=.001), most notably in MBL2 wild-type individuals receiving myeloablative total body irradiation (mTBI). MBL2 coding mutations were associated with major infection in recipients receiving mTBI. The cumulative incidence of major infection in recipient harboring an MBL2 mutation receiving mTBI was 70.6%, compared with 31.1% of those without mutations not receiving mTBI (P=.01). MBL status was not associated with infection in RIC transplants. These results confirm the association of MBL status with risk of infection in myeloablative, TBI-conditioned transplantation. Studies examining the role of MBL replacement therapy to prevent infection in this setting should be considered. 2008 by The American Society of Hematology.

Item Details

Item Type:Refereed Article
Research Division:Mathematical Sciences
Research Group:Numerical and Computational Mathematics
Research Field:Numerical Solution of Differential and Integral Equations
Objective Division:Plant Production and Plant Primary Products
Objective Group:Horticultural Crops
Objective Field:Citrus Fruit
Author:Doherty, KV (Dr Kathleen Doherty)
ID Code:60596
Year Published:2008
Web of Science® Times Cited:34
Deposited By:Faculty of Health
Deposited On:2010-02-12
Last Modified:2012-08-03
Downloads:0

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