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Genetic mapping of the multiple endocrine neoplasia type 1 locus at 11q13
Citation
Teh, BT and Cardinal, J and Shepherd, JJ and Hayward, N and Weber, G and Cameron, D and Larsson, C, Genetic mapping of the multiple endocrine neoplasia type 1 locus at 11q13, Journal of Internal Medicine, 238, (3) pp. 249-253. ISSN 0954-6820 (1995) [Refereed Article]
DOI: doi:10.1111/j.1365-2796.1995.tb00931.x
Abstract
Oncogenesis of tumours related to multiple endocrine neoplasia type 1 (MEN1) is associated with somatic deletions involving the MEN1 locus at chromosomal region 11q13, suggesting inactivation of a tumour-suppressor gene in this region. Here we describe the localization of the MEN1 gene to a 900-kb region, based on linkage analysis in affected families and deletion mapping of MEN1-associated tumours. In addition, a set of microsatellite markers mapped to the 11q11-13 region were used for linkage analysis in a large Tasmanian MEN1 pedigree, demonstrating the usefulness of these markers for presymptomatic testing in affected families.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Research Division: | Biological Sciences |
| Research Group: | Genetics |
| Research Field: | Gene Expression (incl. Microarray and other genome-wide approaches) |
| Objective Division: | Health |
| Objective Group: | Other Health |
| Objective Field: | Health not elsewhere classified |
| UTAS Author: | Shepherd, JJ (Professor Joseph Shepherd) |
| ID Code: | 6058 |
| Year Published: | 1995 |
| Web of Science® Times Cited: | 15 |
| Deposited By: | Surgery |
| Deposited On: | 1995-08-01 |
| Last Modified: | 2011-08-25 |
| Downloads: | 0 |
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