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Genetic mapping of the multiple endocrine neoplasia type 1 locus at 11q13

journal contribution
posted on 2023-05-16, 09:57 authored by Teh, BT, Cardinal, J, Shepherd, JJ, Hayward, N, Weber, G, Cameron, D, Larsson, C
Oncogenesis of tumours related to multiple endocrine neoplasia type 1 (MEN1) is associated with somatic deletions involving the MEN1 locus at chromosomal region 11q13, suggesting inactivation of a tumour-suppressor gene in this region. Here we describe the localization of the MEN1 gene to a 900-kb region, based on linkage analysis in affected families and deletion mapping of MEN1-associated tumours. In addition, a set of microsatellite markers mapped to the 11q11-13 region were used for linkage analysis in a large Tasmanian MEN1 pedigree, demonstrating the usefulness of these markers for presymptomatic testing in affected families.

History

Publication title

Journal of Internal Medicine

Volume

238

Pagination

249-253

ISSN

0954-6820

Department/School

Tasmanian School of Medicine

Publisher

Blackwell Publishing Ltd

Place of publication

Oxford, UK

Repository Status

  • Restricted

Socio-economic Objectives

Other health not elsewhere classified

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