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Iron acquisition by Pseudomonas aeruginosa in the lungs of patients with cystic fibrosis
journal contribution
posted on 2023-05-17, 01:18 authored by Lamont, IL, Konings, AF, Reid, DWThe bacterium Pseudomonas aeruginosa is commonly isolated from the general environment and also infects the lungs of patients with cystic fibrosis (CF). Iron in mammals is not freely available to infecting pathogens although significant amounts of extracellular iron are available in the sputum that occurs in the lungs of CF patients. P. aeruginosa has a large number of systems to acquire this essential nutrient and many of these systems have been characterised in the laboratory. However, which iron acquisition systems are active in CF is not well understood. Here we review recent research that sheds light on how P. aeruginosa obtains iron in the lungs of CF patients.
History
Publication title
BiometalsVolume
22Pagination
53-60ISSN
0966-0844Department/School
Menzies Institute for Medical ResearchPublisher
Kluwer Academic PublPlace of publication
Van Godewijckstraat 30, Dordrecht, Netherlands, 3311 GzRepository Status
- Restricted