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Iron acquisition by Pseudomonas aeruginosa in the lungs of patients with cystic fibrosis
Citation
Lamont, IL and Konings, AF and Reid, DW, Iron acquisition by Pseudomonas aeruginosa in the lungs of patients with cystic fibrosis , Biometals, 22, (1) pp. 53-60. ISSN 0966-0844 (2009) [Refereed Article]
DOI: doi:10.1007/s10534-008-9197-9
Abstract
The bacterium Pseudomonas aeruginosa
is commonly isolated from the general environment
and also infects the lungs of patients with cystic
fibrosis (CF). Iron in mammals is not freely available
to infecting pathogens although significant amounts
of extracellular iron are available in the sputum that
occurs in the lungs of CF patients. P. aeruginosa has
a large number of systems to acquire this essential
nutrient and many of these systems have been
characterised in the laboratory. However, which iron
acquisition systems are active in CF is not well
understood. Here we review recent research that
sheds light on how P. aeruginosa obtains iron in the
lungs of CF patients.
Item Details
Item Type: | Refereed Article |
---|---|
Keywords: | Pseudomonas aeruginosa; Chronic infection; Cystic fibrosis; Iron acquisition; Siderophore; Pyoverdine; Pyochelin; Infectious disease |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Medical microbiology |
Research Field: | Medical bacteriology |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Reid, DW (Dr David Reid) |
ID Code: | 60550 |
Year Published: | 2009 |
Web of Science® Times Cited: | 50 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2010-02-11 |
Last Modified: | 2011-07-28 |
Downloads: | 0 |
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