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Axonopathy and cytoskeletal disruption in degenerative diseases of the central nervous system


Vickers, JC and King, AE and Woodhouse, A and Kirkcaldie, MT and Staal, JA and McCormack, GH and Blizzard, CA and Musgrove, RE and Mitew, S and Liu, Y and Chuckowree, JA and Bibari, O and Dickson, TC, Axonopathy and cytoskeletal disruption in degenerative diseases of the central nervous system , Brain Research Bulletin, 80, (4-5) pp. 217-223. ISSN 0361-9230 (2009) [Refereed Article]

DOI: doi:10.1016/j.brainresbull.2009.08.004


There has been growing interest in the axon as the initial focus of pathological change in a number of neurodegenerative diseases of the central nervous system. This review concentrates on three major neurodegenerative conditions – amyotrophic lateral sclerosis, multiple sclerosis and Alzheimer’s disease – with emphasis on key cellular changes that may underlie early axonal dysfunction and pathology and, potentially, the degeneration of neurons. In particular, this review will address recent data that indicate that the main pathological stimuli for these conditions, though often not definitively determined, result in an initial perturbation of the axon and its cytoskeleton, which then results in slow neuronal degeneration and loss of connectivity. The identification of a degenerative process initiated in the axon may provide new therapeutic targets for early intervention to inhibit the grim outcomes related to the progression of these diseases.

Item Details

Item Type:Refereed Article
Keywords:Axon; Neurodegeneration; Cytoskeleton; Axonopathy; Neurofilament
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Neurology and neuromuscular diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Vickers, JC (Professor James Vickers)
UTAS Author:King, AE (Professor Anna King)
UTAS Author:Woodhouse, A (Dr Adele Woodhouse)
UTAS Author:Kirkcaldie, MT (Dr Matthew Kirkcaldie)
UTAS Author:Staal, JA (Dr Jerome Staal)
UTAS Author:McCormack, GH (Mr Graeme McCormack)
UTAS Author:Blizzard, CA (Dr Catherine Blizzard)
UTAS Author:Musgrove, RE (Dr Ruth Musgrove)
UTAS Author:Mitew, S (Mr Stanislaw Mitew)
UTAS Author:Liu, Y (Professor Yongbing Liu)
UTAS Author:Chuckowree, JA (Dr Jyoti Chuckowree)
UTAS Author:Bibari, O (Dr Olivier Bibari)
UTAS Author:Dickson, TC (Professor Tracey Dickson)
ID Code:60419
Year Published:2009
Web of Science® Times Cited:53
Deposited By:Menzies Institute for Medical Research
Deposited On:2010-02-04
Last Modified:2011-07-28

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