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HLA-DRB1 associations with disease susceptibility and clinical course in Australians with multiple sclerosis

Citation

Stankovich, J and Butzkueven, H and Marriott, M and Chapman, C and Tubridy, N and Tait, BD and Varney, MD and Taylor, BV and Foote, SJ and Booth, DR and Broadley, S and Greer, JM and Griffiths, LR and Heard, RN and Lechner-Scott, J and Pender, MJ and Scott, RJ and Stewart, GJ and Kilpatrick, TJ and Rubio, JP, HLA-DRB1 associations with disease susceptibility and clinical course in Australians with multiple sclerosis, Tissue Antigens, 74, (1) pp. 17-21. ISSN 0001-2815 (2009) [Refereed Article]

DOI: doi:10.1111/j.1399-0039.2009.01262.x

Abstract

Human leucocyte antigen (HLA)-DRB1*1501 and other class II alleles influence susceptibility to multiple sclerosis (MS), but their contribution if any to the clinical course of MS remains uncertain. Here, we have investigated DRB1 alleles in a largesample of 1230 Australian MS cases, with some enrichment for subjects with primary progressive (PPMS) disease (n=246) and 1210 healthy controls. Using logistic regression, we found that DRB1*1501 was strongly associated with risk(P=7 x 10-45), as expected, and after adjusting for DRB1*1501, a predisposing effect was also observed for DRB1*03 (P=5 x 10-7). Individuals homozygous for either DRB1*15 or DRB1*03 were considerably more at risk of MS than heterozygotes and non-carriers. Both the DRB1*04 and the DRB1*01/DRB1*15 genotype combination, respectively, protected against PPMS in comparison to subjects with relapsing disease. Together, these data provide further evidence of heterogeneity at the DRB1 locus and confirm the importance of HLA variants in the phenotypic expression of MS.

Item Details

Item Type:Refereed Article
Keywords:Australians; clinical course; human leucocyte antigen-DRB1; multiple sclerosis; susceptibility
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Central Nervous System
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Stankovich, J (Dr Jim Stankovich)
Author:Taylor, BV (Professor Bruce Taylor)
Author:Foote, SJ (Professor Simon Foote)
ID Code:60410
Year Published:2009
Web of Science® Times Cited:28
Deposited By:Menzies Institute for Medical Research
Deposited On:2010-02-03
Last Modified:2011-07-28
Downloads:0

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