The Role of Aβ-Induced Calcium Dysregulation in the Pathogenesis of Alzheimer’s Disease

Small, DH and Gasperini, R and Vincent, AJ and Hung, AC and Foa, L, The Role of Aβ-Induced Calcium Dysregulation in the Pathogenesis of Alzheimer’s Disease, Journal of Alzheimer's Disease, 16, (2) pp. 225-233. ISSN 1387-2877 (2009) [Refereed Article]

DOI: doi:10.3233/JAD-2009-0951

Abstract

Although many of the biochemical mechanisms which regulate production or clearance of the amyloid-â protein (Aâ)of Alzheimer’s disease (AD) are now well understood, the mechanism of Aâ neurotoxicity remains unclear. A number of studies have shown that Aâ can disrupt neuronal Ca2+ homeostasis by inducing influx of extracellular Ca2+ into the neuronal cytoplasm. Ca2+ is known to play an important role in neuronal excitability, synaptic plasticity and neurotoxicity. Therefore, Aâ-induced Ca2+ dysregulation may contribute to many of the cognitive and neuropathologic features of AD. In vitro studies show that Aâ can increase ion permeability in lipid membranes. This increased permeability is reportedly associated with the formation of artificial ion pores formed from Aâ oligomers. However, a number of other studies show that Aâ can activate endogenous ion channels on the cell surface. There is also increasing evidence that presenilin mutations alter intracellular Ca2+ stores. It is likely that elucidation of the mechanism by which Aâ and presenilin cause Ca2+ dysregulation in neurons will help to identify new drug targets for the treatment of AD.

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