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The Role of Aβ-Induced Calcium Dysregulation in the Pathogenesis of Alzheimer's Disease
Citation
Small, DH and Gasperini, R and Vincent, AJ and Hung, AC and Foa, L, The Role of Aβ-Induced Calcium Dysregulation in the Pathogenesis of Alzheimer's Disease, Journal of Alzheimer's Disease, 16, (2) pp. 225-233. ISSN 1387-2877 (2009) [Refereed Article]
DOI: doi:10.3233/JAD-2009-0951
Abstract
Although many of the biochemical mechanisms which regulate production or clearance of the amyloid-â protein (Aâ)of Alzheimer’s disease (AD) are now well understood, the mechanism of Aâ neurotoxicity remains unclear. A number of studies have shown that Aâ can disrupt neuronal Ca2+ homeostasis by inducing influx of extracellular Ca2+ into the neuronal cytoplasm. Ca2+ is known to play an important role in neuronal excitability, synaptic plasticity and neurotoxicity. Therefore, Aâ-induced Ca2+ dysregulation may contribute to many of the cognitive and neuropathologic features of AD. In vitro studies show that Aâ can increase ion permeability in lipid membranes. This increased permeability is reportedly associated with the formation of artificial ion pores formed from Aâ oligomers. However, a number of other studies show that Aâ can activate endogenous ion channels on the cell surface. There is also increasing evidence that presenilin mutations alter intracellular Ca2+ stores. It is likely that elucidation of the mechanism by which Aâ and presenilin cause Ca2+ dysregulation in neurons will help to identify new drug targets for the treatment of AD.
Item Details
Item Type: | Refereed Article |
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Keywords: | Alzheimer’s disease, amyloid, calcium, neurotoxicity, synaptic plasticity |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Neurosciences |
Research Field: | Neurosciences not elsewhere classified |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Small, DH (Professor David Small) |
UTAS Author: | Gasperini, R (Dr Rob Gasperini) |
UTAS Author: | Vincent, AJ (Dr Adele Vincent) |
UTAS Author: | Hung, AC (Dr Amos Hung) |
UTAS Author: | Foa, L (Professor Lisa Foa) |
ID Code: | 60244 |
Year Published: | 2009 |
Web of Science® Times Cited: | 57 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2010-01-27 |
Last Modified: | 2011-07-28 |
Downloads: | 0 |
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