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Inactivation of retinoblastoma gene in malignant parathyroid growths - A candidate genetic trigger
journal contribution
posted on 2023-05-16, 09:57 authored by Subramaniam, P, Wilkinson, SJ, Shepherd, JJThe molecular basis for parathyroid carcinoma remains undetermined. Parathyroid carcinoma potentially remains curable by early en bloc resection. This requires a reliable diagnostic tool as histological features alone are insufficient to distinguish parathyroid carcinoma from its benign counterpart, parathyroid adenoma. A variety of human cancers arise from the inactivation of the retinoblastoma (RB) gene, a tumour-suppressor gene on chromosome 13q14. We investigated the role of this gene parathyroid growths by using a mouse monoclonal antibody to detect RB gene expression immunohistochemically. Two of the three parathyroid carcinomas in this study showed evidence of RB gene inactivation compared with one of 11 benign parathyroid entities. Three normal parathyroid glands stained showed strong evidence of RB gene expression in all three glands. The relationship between RB gene inactivation and parathyroid malignancy, however, was not statistically significant.
History
Publication title
The Australian and New Zealand Journal of SurgeryVolume
65Issue
10Pagination
714-716ISSN
0004-8682Department/School
Tasmanian School of MedicinePublisher
Blackwell Publishing AsiaPlace of publication
MelbourneRepository Status
- Restricted