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Inactivation of retinoblastoma gene in malignant parathyroid growths - A candidate genetic trigger

journal contribution
posted on 2023-05-16, 09:57 authored by Subramaniam, P, Wilkinson, SJ, Shepherd, JJ
The molecular basis for parathyroid carcinoma remains undetermined. Parathyroid carcinoma potentially remains curable by early en bloc resection. This requires a reliable diagnostic tool as histological features alone are insufficient to distinguish parathyroid carcinoma from its benign counterpart, parathyroid adenoma. A variety of human cancers arise from the inactivation of the retinoblastoma (RB) gene, a tumour-suppressor gene on chromosome 13q14. We investigated the role of this gene parathyroid growths by using a mouse monoclonal antibody to detect RB gene expression immunohistochemically. Two of the three parathyroid carcinomas in this study showed evidence of RB gene inactivation compared with one of 11 benign parathyroid entities. Three normal parathyroid glands stained showed strong evidence of RB gene expression in all three glands. The relationship between RB gene inactivation and parathyroid malignancy, however, was not statistically significant.

History

Publication title

The Australian and New Zealand Journal of Surgery

Volume

65

Issue

10

Pagination

714-716

ISSN

0004-8682

Department/School

Tasmanian School of Medicine

Publisher

Blackwell Publishing Asia

Place of publication

Melbourne

Repository Status

  • Restricted

Socio-economic Objectives

Other health not elsewhere classified

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    University Of Tasmania

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