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The role of host genetics in leishmaniasis
Citation
Sakthianandeswaren, A and Foote, SJ and Handman, E, The role of host genetics in leishmaniasis, Trends in Parasitology, 25, (8) pp. 383-391. ISSN 1471-4922 (2009) [Refereed Article]
DOI: doi:10.1016/j.pt.2009.05.004
Abstract
Leishmaniasis is one of the world's important infectious diseases. It is prevalent in tropical and subtropical regions of the world and endemic in 88 countries, with two million new cases of leishmaniasis reported annually. As a complex disease, the pathology of leishmaniasis varies and is determined by factors such as the environment, the insect vector, and parasite and host genetics. The contributing host genetics involve multiple genes; thus, the mouse model of leishmaniasis has been exploited extensively in an attempt to identify and dissect the contribution of disease modifier genes to pathogenesis. This review summarizes recent advances in the identification of genetic loci involved in the host response to Leishmania spp. in the mouse model and in the human situation. Crown Copyright © 2009.
Item Details
Item Type: | Refereed Article |
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Research Division: | Biomedical and Clinical Sciences |
Research Group: | Clinical sciences |
Research Field: | Infectious diseases |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Foote, SJ (Professor Simon Foote) |
ID Code: | 60055 |
Year Published: | 2009 |
Web of Science® Times Cited: | 89 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2010-01-07 |
Last Modified: | 2010-04-15 |
Downloads: | 0 |
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