Apolipoprotein genotype does not influence MS severity, cognition, or brain atrophy
van der Walt, A and Stankovich, J and Bahlo, M and Taylor, BV and van der Mei, IAF and Foote, SJ and Kilpatrick, TJ and Rubio, JP and Butzkueven, H, Apolipoprotein genotype does not influence MS severity, cognition, or brain atrophy, Neurology, 73, (13) pp. 1018-1025. ISSN 0028-3878 (2009) [Refereed Article]
Background: The influence of APOE allelic heterogeneity on multiple sclerosis (MS) disease severity has been reported in multiple datasets with conflicting results. Several studies have reported an unfavorable association of APOE!4 with more severe clinical disease course while, in contrast, APOE !2 has been associated with a more benign disease course. In this study, we examine the
influence of heterogeneity of the APOE gene on disease severity in a large, Australian, populationbased MS cohort.
Methods: Associations between APOE allele status, 2 promoter region single nucleotide polymorphisms(!219 G/T and "113 C/G), and 4 measures of disease severity were tested in 1,006 patients with relapsing-remitting MS and secondary progressive MS: 1) Multiple Sclerosis Severity Score; 2) Progression Index (Expanded Disability Status Scale/disease duration); 3) age at first
symptom; and 4) interval between the first and second attack. The Symbol Digit Modalities Test was used as a single cognitive marker in 889 patients. Brain atrophy was measured in 792 patients using the intercaudate ratio. APOE!4 and !3 carriers were stratified by!219 G/T or"113
C/G to investigate haplotypic heterogeneity in the APOE gene region.
Results: In this MS study, neither APOE allele status nor promoter region heterogeneity at
positions !219 G/T or "113 C/G influenced the clinical disease severity, cognition, or cerebral
Conclusions: Allelic and haplotypic heterogeneity of the APOE gene region does not influence
multiple sclerosis disease course in this well-defined Australian multiple sclerosis cohort.