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Apolipoprotein genotype does not influence MS severity, cognition, or brain atrophy


van der Walt, A and Stankovich, J and Bahlo, M and Taylor, BV and van der Mei, IAF and Foote, SJ and Kilpatrick, TJ and Rubio, JP and Butzkueven, H, Apolipoprotein genotype does not influence MS severity, cognition, or brain atrophy, Neurology, 73, (13) pp. 1018-1025. ISSN 0028-3878 (2009) [Refereed Article]

DOI: doi:10.1212/WNL.0b013e3181b9c85e


Background: The influence of APOE allelic heterogeneity on multiple sclerosis (MS) disease severity has been reported in multiple datasets with conflicting results. Several studies have reported an unfavorable association of APOE!4 with more severe clinical disease course while, in contrast, APOE !2 has been associated with a more benign disease course. In this study, we examine the influence of heterogeneity of the APOE gene on disease severity in a large, Australian, populationbased MS cohort. Methods: Associations between APOE allele status, 2 promoter region single nucleotide polymorphisms(!219 G/T and "113 C/G), and 4 measures of disease severity were tested in 1,006 patients with relapsing-remitting MS and secondary progressive MS: 1) Multiple Sclerosis Severity Score; 2) Progression Index (Expanded Disability Status Scale/disease duration); 3) age at first symptom; and 4) interval between the first and second attack. The Symbol Digit Modalities Test was used as a single cognitive marker in 889 patients. Brain atrophy was measured in 792 patients using the intercaudate ratio. APOE!4 and !3 carriers were stratified by!219 G/T or"113 C/G to investigate haplotypic heterogeneity in the APOE gene region. Results: In this MS study, neither APOE allele status nor promoter region heterogeneity at positions !219 G/T or "113 C/G influenced the clinical disease severity, cognition, or cerebral atrophy. Conclusions: Allelic and haplotypic heterogeneity of the APOE gene region does not influence multiple sclerosis disease course in this well-defined Australian multiple sclerosis cohort.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Central nervous system
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Stankovich, J (Dr Jim Stankovich)
UTAS Author:Taylor, BV (Professor Bruce Taylor)
UTAS Author:van der Mei, IAF (Professor Ingrid van der Mei)
UTAS Author:Foote, SJ (Professor Simon Foote)
ID Code:60053
Year Published:2009
Web of Science® Times Cited:31
Deposited By:Menzies Institute for Medical Research
Deposited On:2010-01-07
Last Modified:2010-04-16

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