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Fine mapping of multiple sclerosis susceptibility genes provides evidence of allelic heterogeneity at the IL2RA locus

Citation

Perera, DI and Stankovich, J and Butzkueven, H and Taylor, BVM and Foote, SJ and Kilpatrick, TJ and Rubio, JP, Fine mapping of multiple sclerosis susceptibility genes provides evidence of allelic heterogeneity at the IL2RA locus, Journal of Neuroimmunology, 211, (25) pp. 105-109. ISSN 0165-5728 (2009) [Refereed Article]

DOI: doi:10.1016/j.jneuroim.2009.03.010

Abstract

Multiple sclerosis (MS) is a genetically complex autoimmune disease. To dissect further the involvement of four recent identified MS susceptibility genes (KIAA0350, IL2RA, RPL5 and CD58) in disease pathogenesis, we genotyped 94 haplotype-tagging single nucleotide polymorphisms (SNPs) from these loci in 1146 MS cases and 1309 controls. Seven newly-typed SNP variants were nominally associated with risk of MS, and one SNP (rs791589) in the first intron of the IL2RA gene remained associated after adjustment for rs2104286 genotype, a previously reported SNP association. These data provide further evidence of allelic heterogeneity at the IL2RA locus and point to the existence of at least two independent MS susceptibility alleles. © 2009 Elsevier B.V.

Item Details

Item Type:Refereed Article
Keywords:Multiple sclerosis; Fine mapping; Susceptibility gene, <i>IL2RA</i>
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Central Nervous System
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Perera, DI (Miss Devindri Perera)
Author:Stankovich, J (Dr Jim Stankovich)
Author:Taylor, BVM (Professor Bruce Taylor)
Author:Foote, SJ (Professor Simon Foote)
ID Code:60046
Year Published:2009
Web of Science® Times Cited:23
Deposited By:Menzies Institute for Medical Research
Deposited On:2010-01-07
Last Modified:2010-04-15
Downloads:0

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