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Vitamin D3 deficiency enhances contact hypersensitivity in male but not in female mice


Malley, RC and Muller, HK and Norval, M and Woods, GM, Vitamin D3 deficiency enhances contact hypersensitivity in male but not in female mice , Cellular Immunology, 255, (1-2) pp. 33-40. ISSN 0008-8749 (2009) [Refereed Article]

DOI: doi:10.1016/j.cellimm.2008.09.004


To ascertain the influence of vitamin D3 and its metabolites on the function of the skin immune system and the induction of the contact hypersensitivity (CHS) response, a population of vitamin D3-deficient BALB/c mice was established, through dietary vitamin D3 restriction and limitation of exposure to UVB irradiation. Vitamin D3 normal female mice had higher CHS responses than their male counterparts, and dietary vitamin D3 deficiency significantly increased the CHS responses in male, but not in female, mice. This change in the vitamin D3-deficient male mice was not due to an alteration in skin dendritic cell function including antigen carriage, migration or costimulatory molecule expression. In addition, 18 h after sensitisation, the lymph node populations in the vitamin D3-deficient and normal male mice showed similar proliferation and IFN-c production. However, during the sensitisation phase of CHS, there was lower lymphocyte recruitment to the skin draining lymph nodes of the vitamin D3-deficient and normal male mice compared with their female counterparts which could account for the difference between the sexes in the extent of the CHS response. These results indicate the vitamin D system can influence cutaneous immune responses in male mice, but this did not occur through the modulation of the dendritic cell functions analysed.

Item Details

Item Type:Refereed Article
Keywords:Vitamin D; Dendritic cells; Contact hypersensitivity
Research Division:Biomedical and Clinical Sciences
Research Group:Immunology
Research Field:Cellular immunology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Malley, RC (Dr Roslyn Malley)
UTAS Author:Muller, HK (Professor Konrad Muller)
UTAS Author:Woods, GM (Professor Gregory Woods)
ID Code:60042
Year Published:2009
Web of Science® Times Cited:11
Deposited By:Menzies Institute for Medical Research
Deposited On:2010-01-07
Last Modified:2011-07-28

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