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Investigating the role of serotonin in visual orientation processing using an 'ecstasy' (MDMA)- based research model
Citation
Dickson, CR and Bruno, RB and Brown, J, Investigating the role of serotonin in visual orientation processing using an 'ecstasy' (MDMA)- based research model, Neuropsychobiology, 60, (3-4) pp. 204-212. ISSN 0302-282X (2009) [Refereed Article]
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Copyright Statement
Copyright © 2009 S. Karger AG, Basel
Official URL: http://www.karger.com/
Abstract
Aims/Objectives: A growing body of evidence suggests that regular 'ecstasy' (3,4-methylenedioxymethamphetamine) use causes lasting changes to central serotonergic functioning in humans, including in the occipital lobe. Serotonin may play a role in visual orientation processing, mediated in the occipital lobe, via lateral inhibition. The tilt aftereffect is an illusion apparent following adaptation to stimuli angled 5-50° from vertical and thought to be affected by lateral inhibition between occipital neurons. A recent study identified an enhanced tilt aftereffect among ecstasy users, but only in a subset that were recently abstinent from amphetamines. The current study examined the effects of ecstasy use, cannabis use and their interacting effect on the magnitude of the tilt aftereffect among participants with no recent history of amphetamine consumption. Materials and Methods: Eleven ecstasy users, 15 cannabis users, 15 ecstasy plus cannabis users and 15 drug-naïve controls were compared on the magnitude of the tilt aftereffect elicited following adaptation to stimuli angled 15, 30, 40 or 60° from vertical. Results:At a 40° adaptation condition, ecstasy users had a greater magnitude of the tilt aftereffect compared to those that had not taken the drug. Additionally, the extent of ecstasy use was positively associated with the magnitude of the tilt aftereffect generated following 15, 30 and 40° adaptation conditions, but not at 60°. Conclusions:Given that lateral inhibition mediates the tilt aftereffect following adaptation to 5-50°, the findings of a relationship between ecstasy use and tilt magnitude at the 15-40° but not 60° adaptation conditions support a role for serotonin in visual orientation processing via lateral inhibition.
Item Details
Item Type: | Refereed Article |
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Keywords: | 3,4-Methylenedioxymethamphetamine; Ecstasy; Amphetamine; Cannabis; Visual perception; Orientation processing; Occipital lobe; Tilt aftereffect; Serotonin; Later inhibition |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Neurosciences |
Research Field: | Neurosciences not elsewhere classified |
Objective Division: | Health |
Objective Group: | Public health (excl. specific population health) |
Objective Field: | Public health (excl. specific population health) not elsewhere classified |
UTAS Author: | Dickson, CR (Miss Clare Dickson) |
UTAS Author: | Bruno, RB (Associate Professor Raimondo Bruno) |
ID Code: | 60038 |
Year Published: | 2009 |
Web of Science® Times Cited: | 15 |
Deposited By: | Psychology |
Deposited On: | 2010-01-06 |
Last Modified: | 2014-11-27 |
Downloads: | 1 View Download Statistics |
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