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The humoral immune response of the Tasmanian devil (Sarcophilus harrisii) against horse red blood cells

Citation

Kreiss, A and Wells, BB and Woods, GM, The humoral immune response of the Tasmanian devil (Sarcophilus harrisii) against horse red blood cells , Veterinary Immunology and Immunopathology: An International Journal of Comparative Immunology, 130, (1-2) pp. 135-137. ISSN 0165-2427 (2009) [Refereed Article]

DOI: doi:10.1016/j.vetimm.2009.02.003

Abstract

The Tasmanian devil (Sarcophilus harrisii) is under threat of extinction due to a fatal infectious neoplastic disease, named Devil Facial Tumour Disease. Tumours are transferred as allografts between animals and no effective immune response or host resistance to the disease has been detected, raising interest in the immune function of the species. To investigate whether Tasmanian devils had a competent humoral immune response, four devils were immunised with horse red blood cells (HRBC) either intraperitoneally or subcutaneously. Antibody responses were measured by direct and indirect haemagglutination assays for a period of up to 40 weeks. Primary responses were well defined, but secondary responses were prominent only in the devils immunised subcutaneously. All devils showed evidence for a memory antibody response following a booster given 32 weeks after the first injection and this was more evident with the subcutaneous route. Tasmanian devils tested were capable of mounting a humoral immune response against HRBC and the subcutaneous injection in the presence of the adjuvant Montanide was a safe and effective route.

Item Details

Item Type:Refereed Article
Keywords:Tasmanian devil; Humoral immune response; Primary immune response; Memory immune response; Haemagglutination
Research Division:Medical and Health Sciences
Research Group:Immunology
Research Field:Humoural Immunology and Immunochemistry
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Immune System and Allergy
Author:Kreiss, A (Dr Alexandre Kreiss)
Author:Wells, BB (Mr Barrie Wells)
Author:Woods, GM (Professor Gregory Woods)
ID Code:60033
Year Published:2009
Web of Science® Times Cited:15
Deposited By:Menzies Institute for Medical Research
Deposited On:2010-01-06
Last Modified:2011-07-28
Downloads:0

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