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Palladium-mediated organic synthesis using porous polymer monolith formed in situ as a continuous catalyst support structure for application in microfluidic devices

Citation

Goemann, A and Deverell, JA and Munting, KF and Jones, Roderick and Rodemann, T and Canty, AJ and Smith, Jason and Guijt, RM, Palladium-mediated organic synthesis using porous polymer monolith formed in situ as a continuous catalyst support structure for application in microfluidic devices, Tetrahedron, 65, (7) pp. 1450-1454. ISSN 0040-4020 (2009) [Refereed Article]


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DOI: doi:10.1016/j.tet.2008.12.007

Abstract

The development and advantages of in situ synthesis of organic polymer monolith supports for metal pre-catalysts in narrow bore fused silica capillary microreactors are described. Catalyst immobilisation involves the covalent attachment of ligand binding sites to the porous polymer monolith, followed by coordination to metal centres. Flow-through microreactors using poly(chloromethylstyrene-co-divinylbenzene) monolith in capillaries of internal diameter 250 ìm were used successfully for Suzuki–Miyaura and Sonogashira reactions, utilising both 1,10-phenanthroline and imidazole/carbene binding to palladium and with very low palladium leaching, illustrating the potential of flow-through technology at the microscale level using organic monolith support for transition metal catalysed reactions.

Item Details

Item Type:Refereed Article
Keywords:Microreactor; Catalysis; Microfluidic; Monolith; Flow-through
Research Division:Chemical Sciences
Research Group:Other Chemical Sciences
Research Field:Organometallic Chemistry
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Chemical Sciences
Author:Goemann, A (Dr Anissa Goemann)
Author:Deverell, JA (Dr Jeremy Deverell)
Author:Munting, KF (Mrs Katrina Munting)
Author:Jones, Roderick (Dr Roderick Jones)
Author:Rodemann, T (Dr Thomas Rodemann)
Author:Canty, AJ (Professor Allan Canty)
Author:Smith, Jason (Associate Professor Jason Smith)
Author:Guijt, RM (Dr Rosanne Guijt)
ID Code:59946
Year Published:2009
Funding Support:Australian Research Council (DP0663416)
Web of Science® Times Cited:60
Deposited By:Austn Centre for Research in Separation Science
Deposited On:2009-12-23
Last Modified:2011-08-12
Downloads:0

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