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Correlates of Subchondral BMD: A Cross-Sectional Study

Citation

Dore, D and Quinn, S and Ding, C and Winzenberg, T and Jones, G, Correlates of Subchondral BMD: A Cross-Sectional Study, Journal of Bone and Mineral Research, 24, (12) pp. 2007-2015. ISSN 0884-0431 (2009) [Refereed Article]

DOI: doi:10.1359/JBMR.090532

Abstract

Subchondral bone is hypothesized to be important in the development and progression of osteoarthritis (OA); however, little is known about the determinants of subchondral bone. This study describes the relationship between tibial subchondral BMD (sBMD) and anthropometric, lifestyle, and structural measures in 740 randomly selected subjects (mean age, 62 yr; range, 50–80 yr; 52% women). We measured medial tibial sBMD by DXA at two regions of interest (ROIs). We also assessed anthropometrics, vitamin D, steps per day by pedometer, joint space narrowing (JSN) and osteophytes (by X-ray), cartilage defects, cartilage volume, and bone marrow lesions (BML; by MRI), and hip and spine BMD (by DXA). sBMD using ROI 1 was negatively associated with age and female sex and positively associated with BMI. In multivariable analysis, sBMD was positively correlated with steps per day (r = 0.08, p = 0.025), tibial osteophytes (r = 0.08, p = 0.028), JSN (r = 0.11, p < 0.01), cartilage defects (r = 0.16, p < 0.01), cartilage volume (r = 0.12, p = 0.01), BMLs (r = 0.17, p = 0.013 [tibial]; r = 0.16, p = 0.018 [femoral]), and hip and spine BMD (r = 0.36, p < 0.01 and r = 0.38, p < 0.01, respectively). Similar associations were observed using ROI 2, with vitaminDalso associated with sBMD (r = 0.10, p < 0.01). In conclusion, this study identified a large number of factors associated with sBMD, of which the most novel is cartilage defects. Longitudinal studies are required to address causality.

Item Details

Item Type:Refereed Article
Keywords:osteoarthritis, subchondral bone, DXA, cross-sectional, MRI
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
Author:Dore, D (Dr Dawn Aitken)
Author:Quinn, S (Dr Stephen Quinn)
Author:Ding, C (Professor Chang-Hai Ding)
Author:Winzenberg, T (Professor Tania Winzenberg)
Author:Jones, G (Professor Graeme Jones)
ID Code:59678
Year Published:2009
Web of Science® Times Cited:32
Deposited By:Menzies Institute for Medical Research
Deposited On:2009-12-16
Last Modified:2010-04-15
Downloads:0

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