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Correlates of Subchondral BMD: A Cross-Sectional Study
journal contribution
posted on 2023-05-17, 00:56 authored by Dawn AitkenDawn Aitken, Quinn, S, Chang-Hai DingChang-Hai Ding, Tania WinzenbergTania Winzenberg, Graeme JonesGraeme JonesSubchondral bone is hypothesized to be important in the development and progression of osteoarthritis (OA); however, little is known about the determinants of subchondral bone. This study describes the relationship between tibial subchondral BMD (sBMD) and anthropometric, lifestyle, and structural measures in 740 randomly selected subjects (mean age, 62 yr; range, 50–80 yr; 52% women). We measured medial tibial sBMD by DXA at two regions of interest (ROIs). We also assessed anthropometrics, vitamin D, steps per day by pedometer, joint space narrowing (JSN) and osteophytes (by X-ray), cartilage defects, cartilage volume, and bone marrow lesions (BML; by MRI), and hip and spine BMD (by DXA). sBMD using ROI 1 was negatively associated with age and female sex and positively associated with BMI. In multivariable analysis, sBMD was positively correlated with steps per day (r = 0.08, p = 0.025), tibial osteophytes (r = 0.08, p = 0.028), JSN (r = 0.11, p < 0.01), cartilage defects (r = 0.16, p < 0.01), cartilage volume (r = 0.12, p = 0.01), BMLs (r = 0.17, p = 0.013 [tibial]; r = 0.16, p = 0.018 [femoral]), and hip and spine BMD (r = 0.36, p < 0.01 and r = 0.38, p < 0.01, respectively). Similar associations were observed using ROI 2, with vitaminDalso associated with sBMD (r = 0.10, p < 0.01). In conclusion, this study identified a large number of factors associated with sBMD, of which the most novel is cartilage defects. Longitudinal studies are required to address causality.
History
Publication title
Journal of Bone and Mineral ResearchVolume
24Issue
12Pagination
2007-2015ISSN
0884-0431Department/School
Menzies Institute for Medical ResearchPublisher
Amer Soc Bone & Mineral ResPlace of publication
2025 M St, N W, Ste 800, Washington, USA, Dc, 20036-3309Repository Status
- Restricted