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Incidence of Stroke Subtypes in the North East Melbourne Stroke Incidence Study (NEMESIS): Differences between Men and Women


Thrift, AG and Dewey, HM and Sturm, JW and Srikanth, VK and Gilligan, AK and Gall, SL and Macdonell, RAL and McNeil, JJ and Donnan, GA, Incidence of Stroke Subtypes in the North East Melbourne Stroke Incidence Study (NEMESIS): Differences between Men and Women , Neuroepidemiology, 32, (1) pp. 11-18. ISSN 0251-5350 (2009) [Refereed Article]

DOI: doi:10.1159/000170086


Background and Purpose: Incidence rates of stroke subtypes may be imprecise when samples are small. We aimed to determine the incidence of stroke subtypes in a large geographically defined population. Methods: Multiple overlapping sources were used to ascertain all strokes occurring in 22 postcodes (population of 306,631) of Melbourne, Australia, between 1997 and 1999. Stroke subtypes were defined by CT, MRI and autopsy. The Mantel-Haenszel age-adjusted rate ratio (MH RR) was used to compare incidence rates between men and women. Results: We identified 1,421 strokes among 1,337 residents, 1,035 (72.8%) being first-ever strokes. Incidence (number/100,000 population/year), adjusted to the European population 45–84 years, was 197 (95% confidence interval, CI, 169–224) for ischemic stroke (IS), 47 (95% CI 33–60) for intracerebral haemorrhage (ICH) and 19 (95% CI 10–27) for subarachnoid haemorrhage (SAH). Compared with women, men in this age group had a greater incidence of IS (MH RR 1.65, 95% CI 1.39–1.96, p<0.0001) and ICH (MH RR 1.46, 95% CI 1.01–2.10, p = 0.0420), but lesser rates of SAH (MH RR 0.34, 95% CI 0.16–0.69, p = 0.0031). Conclusions: In this population-based study, the incidence of IS and ICH was greater among men than women, while women had a greater incidence of SAH. More effort may need to be directed at modifying risk factors for IS and ICH in men.

Item Details

Item Type:Refereed Article
Keywords:Cerebrovascular disorders; Epidemiology; Incidence stroke; Intracerebral haemorrhage; Ischemic stroke; Subarachnoid haemorrhage
Research Division:Health Sciences
Research Group:Epidemiology
Research Field:Epidemiology not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Gall, SL (Associate Professor Seana Gall)
ID Code:59237
Year Published:2009
Web of Science® Times Cited:51
Deposited By:Menzies Institute for Medical Research
Deposited On:2009-11-26
Last Modified:2011-07-28

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