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Past environmental sun exposure and risk of multiple sclerosis: a role for the Cdx-2 Vitamin D receptor variant in this interaction

Citation

Dickinson, JL and Perera, DI and van der Mei, AF and Ponsonby, AL and Polanowski, AM and Thomson, RJ and Taylor, BV and McKay, JD and Stankovich, J and Dwyer, T, Past environmental sun exposure and risk of multiple sclerosis: a role for the Cdx-2 Vitamin D receptor variant in this interaction , Multiple Sclerosis, 15, (5) pp. 563-570. ISSN 1352-4585 (2009) [Refereed Article]

DOI: doi:10.1177/1352458509102459

Abstract

Multiple studies have provided evidence for an association between reduced sun exposure and increased risk of multiple sclerosis (MS), an association likely to be mediated, at least in part, by the vitamin D hormonal pathway. Herein, we examine whether the vitamin D receptor (VDR), an integral component of this pathway, influences MS risk in a population-based sample where winter sun exposure in early childhood has been found to be an important determinant of MS risk. Three polymorphisms within the VDR gene were genotyped in 136 MS cases and 235 controls, and associations with MS and past sun exposure were examined by logistic regression. No significant univariate associations between the polymorphisms, rs11574010 (Cdx-2A> G), rs1 0735810 (FoklT> C), or rs731236 (Taq1 C > T) and MS risk were observed. However, a significant interaction was observed between winter sun exposure during childhood, genotype at rsl1574010, and MS risk (P = 0.012), with the 'G' allele conferring an increased risk of MS in the low sun exposure group (~2 h/day). No significant interactions were observed for either rs10735810 or rs731236, after stratification by sun exposure. These data provide support for the involvement of the VDR gene in determining MS risk, an interaction likely to be dependent on past sun exposure. Multiple Sclerosis 2009; 15: 563-570. http://msj.sagepub.com

Item Details

Item Type:Refereed Article
Keywords:environment; genetic polymorphisms; multiple sclerosis; receptor calcitrol
Research Division:Biological Sciences
Research Group:Genetics
Research Field:Genetics not elsewhere classified
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Dickinson, JL (Associate Professor Joanne Dickinson)
Author:Perera, DI (Miss Devindri Perera)
Author:van der Mei, AF (Associate Professor Ingrid van der Mei)
Author:Ponsonby, AL (Professor Anne Ponsonby)
Author:Polanowski, AM (Ms Andrea Polanowski)
Author:Thomson, RJ (Dr Russell Thomson)
Author:Taylor, BV (Professor Bruce Taylor)
Author:Stankovich, J (Dr Jim Stankovich)
Author:Dwyer, T (Professor Terry Dwyer)
ID Code:59101
Year Published:2009
Web of Science® Times Cited:56
Deposited By:Menzies Institute for Medical Research
Deposited On:2009-11-18
Last Modified:2011-07-28
Downloads:0

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