File(s) not publicly available
Past environmental sun exposure and risk of multiple sclerosis: a role for the Cdx-2 Vitamin D receptor variant in this interaction
journal contribution
posted on 2023-05-17, 00:40 authored by Joanne DickinsonJoanne Dickinson, Perera, DI, Ingrid van der MeiIngrid van der Mei, Ponsonby, AL, Polanowski, AM, Russell Thomson, Bruce TaylorBruce Taylor, McKay, JD, Jim Stankovich, Terry DwyerTerry DwyerMultiple studies have provided evidence for an association between reduced sun exposure and increased risk of multiple sclerosis (MS), an association likely to be mediated, at least in part, by the vitamin D hormonal pathway. Herein, we examine whether the vitamin D receptor (VDR), an integral component of this pathway, influences MS risk in a population-based sample where winter sun exposure in early childhood has been found to be an important determinant of MS risk. Three polymorphisms within the VDR gene were genotyped in 136 MS cases and 235 controls, and associations with MS and past sun exposure were examined by logistic regression. No significant univariate associations between the polymorphisms, rs11574010 (Cdx-2A> G), rs1 0735810 (FoklT> C), or rs731236 (Taq1 C > T) and MS risk were observed. However, a significant interaction was observed between winter sun exposure during childhood, genotype at rsl1574010, and MS risk (P = 0.012), with the 'G' allele conferring an increased risk of MS in the low sun exposure group (~2 h/day). No significant interactions were observed for either rs10735810 or rs731236, after stratification by sun exposure. These data provide support for the involvement of the VDR gene in determining MS risk, an interaction likely to be dependent on past sun exposure. Multiple Sclerosis 2009; 15: 563-570. http://msj.sagepub.com
History
Publication title
Multiple SclerosisVolume
15Issue
5Pagination
563-570ISSN
1352-4585Department/School
Menzies Institute for Medical ResearchPublisher
ArnoldPlace of publication
Hodder Headline Plc, 338 Euston Road, London, England, Nw1 3BhRepository Status
- Restricted