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Assessment of arterial stiffness, oxidative stress and inflammation in acute kidney injury

Citation

Fassett, RG and D'Intini, V and Healy, H and Gowardman, J and Gan, J and Sharman, JE and Coombes, JS, Assessment of arterial stiffness, oxidative stress and inflammation in acute kidney injury , BMC Nephrology, 10, (15) EJ ISSN 1471-2369 (2009) [Refereed Article]

DOI: doi:10.1186/1471-2369-10-15

Abstract

Background: It is well know that arterial stiffness, oxidative stress and inflammation are features of chronic kidney disease. The arterial changes have a multitude of potential interconnected causes including endothelial dysfunction, oxidative stress, inflammation, atherosclerosis and vascular calcification. There is evidence that arterial stiffness becomes progressively worse as CKD progresses. The contribution of the biochemical changes of uremic toxicity to arterial stiffness is less clear. The aim of this study is to elucidate the vascular changes in acute kidney injury. We hypothesise that arterial stiffness will be increased during acute kidney injury and this will return to normal after kidney function recovers. Methods/Design: One hundred and forty four patients with acute kidney injury defined as an acute increase in serum creatinine to > 133 ýmol/l or urea > 14.3 mmol/l or urine output < 410ml/day will be recruited. Baseline measures of aortic pulse wave velocity, augmentation index, and brachial and central blood pressure will be recorded along with blood measures for oxidative stress and inflammation. Repeat measures will be taken at six and 12 months after the onset of the acute kidney injury. Discussion: The role and contribution of the biochemical changes to arterial stiffness in the acute phase of kidney disease is not known. This study will primarily assess the time course changes in pulse wave velocity from the onset of acute kidney injury and after recovery. In addition it will assess augmentation index, central blood pressure and oxidative stress and inflammation. This may shed light on the contribution of biochemical kidney toxins on arterial stiffness in both acute kidney injury and chronic kidney disease. Trial Registration: ACTRN 12609000285257

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Nephrology and Urology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cardiovascular System and Diseases
Author:Sharman, JE (Professor James Sharman)
ID Code:59094
Year Published:2009
Web of Science® Times Cited:4
Deposited By:Menzies Institute for Medical Research
Deposited On:2009-11-17
Last Modified:2010-04-15
Downloads:0

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