eCite Digital Repository

Obesity and Menstrual Irregularity: Associations With SHBG, Testosterone, and Insulin


Wei, S and Schmidt, MD and Dwyer, T and Norman, RJ and Venn, AJ, Obesity and Menstrual Irregularity: Associations With SHBG, Testosterone, and Insulin, Obesity, 17, (5) EJ ISSN 1930-7381 (2009) [Refereed Article]

DOI: doi:10.1038/oby.2008.641


This cross-sectional study aimed to examine the association between different body composition measures, menstrual cycle characteristics, and hormonal factors in a population-based sample of young women. The study sample included 726 Australian women aged 26–36 years who were not currently taking hormonal contraceptives and were not currently pregnant or breast feeding. Anthropometric measures included BMI, waist circumference (WC), and waist–hip ratio (WHR). Menstrual cycle characteristics were self-reported and usual cycles defined as short ( 25 days), normal (26–34 days), or long ( 35 days). Cycles were defined as irregular if there were 15 days between the longest and shortest cycle in the past 12 months. Fasting serum levels of sex hormone-binding globulin (SHBG), testosterone, insulin, and glucose were measured and the free androgen index (FAI) derived. Compared with those of normal weight, obese women had at least a twofold greater odds of having an irregular cycle, whether defined by BMI (odds ratio (OR) = 2.61; 95% CI = 1.28–5.35), WC (OR 2.28; 95% CI = 1.16–4.49), or WHR (OR = 2.27; 95% CI = 1.09–4.72). Body composition measures were significantly positively associated with fasting insulin, testosterone, and FAI, and negatively associated with SHBG ( P < 0.01). Fasting insulin, SHBG, and FAI had the strongest influence on the associations between obesity and irregular cycles, with statistically significant ORs of having an irregular cycle being attenuated to near null values following adjustment. In conclusion, both overall and central obesity were significantly associated with having an irregular menstrual cycle. This association was substantially influenced by hormonal factors, particularly insulin and SHBG.

Item Details

Item Type:Refereed Article
Research Division:Health Sciences
Research Group:Epidemiology
Research Field:Epidemiology not elsewhere classified
Objective Division:Health
Objective Group:Specific population health (excl. Indigenous health)
Objective Field:Women's and maternal health
UTAS Author:Wei, S (Mrs Shuying Wei)
UTAS Author:Schmidt, MD (Dr Michael Schmidt)
UTAS Author:Venn, AJ (Professor Alison Venn)
ID Code:59044
Year Published:2009
Web of Science® Times Cited:96
Deposited By:Menzies Institute for Medical Research
Deposited On:2009-11-17
Last Modified:2010-04-16

Repository Staff Only: item control page