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Direct enantioselective HPLC monitoring of lipase-catalyzed kinetic resolution of flurbiprofen

Citation

Ghanem, A, Direct enantioselective HPLC monitoring of lipase-catalyzed kinetic resolution of flurbiprofen, Chirality, 22, (6) pp. 597-603. ISSN 0899-0042 (2010) [Refereed Article]


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Copyright Statement

The definitive published version is available online at: http://www.interscience.wiley.com

Official URL: http://interscience.wiley.com

DOI: doi:10.1002/chir.20798

Abstract

The solvent versatility of Chiralpak IB, a 3,5-dimethylphenylcarbamate derivative of cellulose-based chiral stationary phase, is demonstrated in the direct enantioselective HPLC monitoring of lipase-catalyzed kinetic resolution of flurbiprofen in nonstandard HPLC organic solvents. Nonstandard HPLC organic solvents were used as the reaction media for the lipase-catalysis and in mean time as diluent to dissolve the difficult to dissolve enzyme substrate (the acid) and as eluent for the simultaneous enantioselective HPLC baseline separation of both substrate and product in one run without any further derivatization.

Item Details

Item Type:Refereed Article
Keywords:chiral separation chiralpak IB direct monitoring enantioselective HPLC flurbiprofen HPLC kinetic resolution lipase
Research Division:Chemical Sciences
Research Group:Analytical Chemistry
Research Field:Separation Science
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Chemical Sciences
Author:Ghanem, A (Dr Ashraf Ghanem)
ID Code:59004
Year Published:2010
Web of Science® Times Cited:8
Deposited By:Austn Centre for Research in Separation Science
Deposited On:2009-11-12
Last Modified:2011-05-04
Downloads:0

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