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Direct enantioselective HPLC monitoring of lipase-catalyzed kinetic resolution of flurbiprofen
Citation
Ghanem, A, Direct enantioselective HPLC monitoring of lipase-catalyzed kinetic resolution of flurbiprofen, Chirality, 22, (6) pp. 597-603. ISSN 0899-0042 (2010) [Refereed Article]
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Abstract
The solvent versatility of Chiralpak IB, a 3,5-dimethylphenylcarbamate derivative of cellulose-based chiral stationary phase, is demonstrated in the direct enantioselective HPLC monitoring of lipase-catalyzed kinetic resolution of flurbiprofen in nonstandard HPLC organic solvents. Nonstandard HPLC organic solvents were used as the reaction media for the lipase-catalysis and in mean time as diluent to dissolve the difficult to dissolve enzyme substrate (the acid) and as eluent for the simultaneous enantioselective HPLC baseline separation of both substrate and product in one run without any further derivatization.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | chiral separation • chiralpak IB • direct monitoring • enantioselective HPLC • flurbiprofen • HPLC • kinetic resolution • lipase |
| Research Division: | Chemical Sciences |
| Research Group: | Analytical Chemistry |
| Research Field: | Separation Science |
| Objective Division: | Expanding Knowledge |
| Objective Group: | Expanding Knowledge |
| Objective Field: | Expanding Knowledge in the Chemical Sciences |
| Author: | Ghanem, A (Dr Ashraf Ghanem) |
| ID Code: | 59004 |
| Year Published: | 2010 |
| Web of Science® Times Cited: | 8 |
| Deposited By: | Austn Centre for Research in Separation Science |
| Deposited On: | 2009-11-12 |
| Last Modified: | 2011-05-04 |
| Downloads: | 0 |
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