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Serum Levels of Vitamin D, Sunlight Exposure, and Knee Cartilage Loss in Older Adults

Citation

Ding, C and Cicuttini, F and Parameswaran, V and Burgess, JR and Quinn, SJ and Jones, G, Serum Levels of Vitamin D, Sunlight Exposure, and Knee Cartilage Loss in Older Adults, Arthritis and Rheumatism, 60, (5) pp. 1381-1389. ISSN 0004-3591 (2009) [Refereed Article]

DOI: doi:10.1002/art.24486

Abstract

Objective. To determine the associations between serum levels of vitamin D, sunlight exposure, and knee cartilage loss cross-sectionally and longitudinally in older adults. Methods. A total of 880 randomly selected subjects (mean age 61 years [range 51–79 years], 50% women) were studied at baseline, and 353 of these subjects were studied 2.9 years later. Serum levels of 25-hydroxyvitamin D (25[OH]D) were assessed by radioimmunoassay, and sunlight exposure was assessed by questionnaire. T1-weighted fat-suppressed magnetic resonance imaging (MRI) of the right knee was performed to determine knee cartilage volume and defects. Knee radiographic osteoarthritis (OA) and knee pain were also assessed. Results. The mean 25(OH)D serum level was 52.8 nmoles/liter at baseline (range 13–119 nmoles/liter). Winter sunlight exposure and serum 25(OH)D level were both positively associated with medial and lateral tibial cartilage volume, and a serum 25(OH)D level <50 nmoles/liter was associated with increased medial tibiofemoral joint space narrowing (all P < 0.05). Longitudinally,baseline serum 25(OH)D level predicted change in both medial and lateral tibial cartilage volume ( 0.04% per annum per nmole/liter for both; P < 0.05), and change in serum 25(OH)D level was positively associated with change in medial tibial cartilage volume. These associations were consistent in subjects with radiographic OA and knee pain and/or in women, but not in men or in subjects without radiographic OA or knee pain. Conclusion. Sunlight exposure and serum 25(OH)D levels are both associated with decreased knee cartilage loss (assessed by radiograph or MRI). This is best observed using the whole range of 25(OH)D levels rather than predefined cut points and implies that achieving vitamin D sufficiency may prevent and/or retard cartilage loss in knee OA.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
Author:Ding, C (Professor Chang-Hai Ding)
Author:Burgess, JR (Professor John Burgess)
Author:Quinn, SJ (Dr Stephen Quinn)
Author:Jones, G (Professor Graeme Jones)
ID Code:58994
Year Published:2009
Web of Science® Times Cited:77
Deposited By:Menzies Institute for Medical Research
Deposited On:2009-11-11
Last Modified:2010-04-15
Downloads:0

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