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Genetic analysis of skull shape variation and morphological integration in the mouse using interspecific recombinant congenic strains between C57BL/6 and mice of the Mus spretus species

Citation

Burgio, G and Baylac, M and Heyer, E and Montagutelli, X, Genetic analysis of skull shape variation and morphological integration in the mouse using interspecific recombinant congenic strains between C57BL/6 and mice of the Mus spretus species, Evolution: International Journal of Organic Evolution, 63, (10) pp. 2668-2686. ISSN 0014-3820 (2009) [Refereed Article]

DOI: doi:10.1111/j.1558-5646.2009.00737.x

Abstract

To assess the genetic basis of the skull shape variation and morphological integration in mice, we have used a tool based on the cross between the distantly related mouse species Mus spretus (SEG/Pas strain) and the laboratory strain C57BL/6 called interspecific recombinant congenic strains (IRCSs). The genome of each IRCS consists on average of 1.3% of SEG/Pas derived sequences, located on multiple chromosomes as small-sized, DNA segments. Quantitative trait loci (QTL) on the skull shape, separated into dorsal and ventral sides, were analyzed in 17 IRCSs by a Procrustes superimposition method using 3D landmarks. The shapes of 16 strains differed significantly from C57BL/6. Discrepancy in the QTLs effects was found between the dorsal side and the anterior region of the ventral side due to a differential effect of the SEG/Pas alleles on the skull shape. A comprehensive analysis of all allelic combinations of the BCG-66H strain showed strong epistatic interactions between SEG/Pas segment acting on both skull sides. Epistatic pleiotropy and covariation between sides were dependent in SEG/Pas alleles direction and contributed to the strong morphological integration between sides. Introduction of Mus spretus alleles in a C57BL/6 background induced strong morphological changes mostly in SEG/Pas alleles direction and provided evidence for high level of morphological integration.

Item Details

Item Type:Refereed Article
Keywords:Covariation between traits, epistasis, fluctuating asymmetry, pleiotropy, Procrustes superimposition, quantitative trait loci
Research Division:Biological Sciences
Research Group:Evolutionary Biology
Research Field:Evolution of Developmental Systems
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Environmental Sciences
Author:Burgio, G (Dr Gaetan Burgio)
ID Code:58896
Year Published:2009
Web of Science® Times Cited:28
Deposited By:Menzies Institute for Medical Research
Deposited On:2009-11-04
Last Modified:2010-04-14
Downloads:0

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