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Statin therapy, muscle function and falls risk in community-dwelling older adults

Citation

Scott, D and Blizzard, L and Fell, J and Jones, G, Statin therapy, muscle function and falls risk in community-dwelling older adults, Q J M: Monthly Journal of The Association of Physicians, 102, (9) pp. 625-633. ISSN 1460-2725 (2009) [Refereed Article]

DOI: doi:10.1093/qjmed/hcp093

Abstract

Background: Statin therapy can cause myopathy, however it is unclear whether this exacerbates age-related muscle function declines. Aim: To describe differences between statin users and non-users in muscle mass, muscle function and falls risk in a group of community-dwelling older adults. Design: A prospective, population-based cohort study with a mean follow-up of 2.6 years. Methods: Total 774 older adults [48% female; mean (standard deviation) age = 62 (7) years] were examined at baseline and follow-up. Differences in percentage appendicular lean mass (%ALM), leg strength, leg muscle quality (LMQ; specific force) and falls risk were compared for statin users and non-users. Results: There were 147 (19%) statin users at baseline and 179 (23%) at follow-up. Longitudinal analyses revealed statin use at baseline predicted increased falls risk scores over 2.6 years (0.14,95% CI 0.01 to 0.27) and a trend towards increased %ALM (0.45%, 95% CI –0.01 to 0.92). Statin users at both time points demonstrated decreased leg strength (–5.02 kg, 95% CI –9.65 to –0.40) and LMQ (–0.30 kg/kg, 95% CI –0.59 to 0.01), and trended towards increased falls risk (0.13, 95% CI –0.01 to 0.26) compared to controls. Finally, statin users at both baseline and follow-up demonstrated decreased leg strength (–16.17 kg, 95% CI –30.19 to –2.15) and LMQ (–1.13 kg/kg, 95% CI –2.02 to –0.24) compared to those who had ceased statin use at follow-up. Conclusion: Statin use may exacerbate muscle performance declines and falls risk associated with aging without a concomitant decrease in muscle mass, and this effect may be reversible with cessation.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Public Health and Health Services
Research Field:Epidemiology
Objective Division:Health
Objective Group:Specific Population Health (excl. Indigenous Health)
Objective Field:Health Related to Ageing
Author:Scott, D (Mr David Scott)
Author:Blizzard, L (Professor Leigh Blizzard)
Author:Fell, J (Associate Professor James Fell)
Author:Jones, G (Professor Graeme Jones)
ID Code:58889
Year Published:2009
Web of Science® Times Cited:68
Deposited By:Menzies Institute for Medical Research
Deposited On:2009-11-04
Last Modified:2010-04-16
Downloads:0

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