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Toenail onychomycosis: an important global disease burden


Thomas, Jackson and Jacobson, GA and Narkowicz, CK and Peterson, GM and Burnet, H and Sharpe, C, Toenail onychomycosis: an important global disease burden, Journal of Clinical Pharmacy and Therapeutics, 35, (5) pp. 497-519. ISSN 0269-4727 (2010) [Refereed Article]

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DOI: doi:10.1111/j.1365-2710.2009.01107.x


Onychomycosis is a fungal infection of the nail plate or nail bed. It does not usually cure itself and it can trigger more infectious lesions in other parts of the body. The reported prevalence of onychomycosis is increasing in Western countries, presumably due to lifestyle changes and the ageing of the population. Approximately 10% of the general population, 20% of the population aged >60 years, up to 50% of people aged >70 years and up to one-third of diabetic individuals have onychomycosis. Care should be taken for the accurate diagnosis and timely treatment of toenail onychomycosis to prevent complications. Current treatment options have relatively limited therapeutic success, particularly long-term. Oral medications are associated with high recurrence rates and treatment failure, and are not suitable for many cases due to potential adverse effects. Topical medications are recommended only for mild to moderate cases. The cost of therapies may also be prohibitive in some cases. In the light of these issues, more research is warranted for the investigation and development of more effective and economical options for the treatment and prophylaxis of toenail onychomycosis. In patient populations such as diabetic individuals, where onychomycosis can provoke lower extremity complications, professional podiatry care of toenails and feet should be encouraged.

Item Details

Item Type:Refereed Article
Keywords:dermatophytes, diagnosis, epidemiology. onychomycosis, toenail, treatment
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Pharmaceutical sciences
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Thomas, Jackson (Mr Jackson Thomas)
UTAS Author:Jacobson, GA (Professor Glenn Jacobson)
UTAS Author:Narkowicz, CK (Dr Christian Narkowicz)
UTAS Author:Peterson, GM (Professor Gregory Peterson)
ID Code:58726
Year Published:2010
Web of Science® Times Cited:166
Deposited By:Pharmacy
Deposited On:2009-10-20
Last Modified:2017-04-11
Downloads:4 View Download Statistics

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