eCite Digital Repository
Solar simulated ultraviolet radiation damages murine neonatal skin and alters Langerhans cell development, but does not induce inflammation
Citation
McGee, HM and Dharmadasa, T and Woods, GM, Solar simulated ultraviolet radiation damages murine neonatal skin and alters Langerhans cell development, but does not induce inflammation, Photochemical & Photobiological Sciences, 8, (6) pp. 881-886. ISSN 1474-905X (2009) [Refereed Article]
DOI: doi:10.1039/b822591e
Abstract
Development of melanoma has been linked to excessive childhood exposure to sunlight. As neonates have a relatively underdeveloped immune system, it is likely that the immune system reacts differently to the exposure, leading to alterations in this development. This study was designed to assess changes in
development of the skin immune system following neonatal irradiation. Ultraviolet radiation exposure led to relative depletion of Langerhans cells, however this was not due to migration or cell death, but rather restriction of Langerhans cells populating the epidermis. During this time, there was evidence of cellular damage, however there was no induction of an inflammatory response. It therefore appears that neonatal exposure to ultraviolet radiation leads to a skew towards a tolerogenic immune response, which may lead to a reduced ability to respond to ultraviolet radiation-induced tumours.
Item Details
Item Type: | Refereed Article |
---|---|
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Immunology |
Research Field: | Cellular immunology |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | McGee, HM (Dr Heather McGee) |
UTAS Author: | Dharmadasa, T (Miss Dharmadasa) |
UTAS Author: | Woods, GM (Professor Gregory Woods) |
ID Code: | 58574 |
Year Published: | 2009 |
Web of Science® Times Cited: | 2 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2009-10-14 |
Last Modified: | 2010-04-15 |
Downloads: | 0 |
Repository Staff Only: item control page