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Leukemia Inhibitory Factor Arrests Oligodendrocyte Death and Demyelination in Spinal Cord Injury
Citation
Azari, MF and Profyris, C and Small, DH and Karnezis, T and Bernard, CC, Leukemia Inhibitory Factor Arrests Oligodendrocyte Death and Demyelination in Spinal Cord Injury, Journal of Neuropathology and Experimental Neurology, 65, (9) pp. 914-929. ISSN 0022-3069 (2006) [Refereed Article]
DOI: doi:10.1097/01.jnen.0000235855.77716.25
Abstract
As a consequence of secondary pathophysiological mechanisms
elicited after spinal cord injury (SCI), oligodendrocytes die by waves
of apoptosis. This ultimately results in demyelination of intact axons
leading to a loss of their conducting properties. Preservation of as few
as 5% to 10% of myelinated axons in individual tracts can confer
locomotor recovery. Thus, strategies aimed at rescuing mature
oligodendrocytes ensheathing viable axons are likely to be of
therapeutic significance. We report that leukemia inhibitory factor
(LIF) can prevent oligodendrocyte apoptosis, notably contralateral to
the spinal cord lesion, through the induction of the JAK/STAT and Akt
signaling pathways as well as by potentiating the expression of the
antiapoptotic molecule, cIAP2. Reduced oligodendrocyte apoptosis
after SCI with LIF administration resulted in a substantial decrease in
demyelination shown by the preservation of lamellated myelin
surrounding viable axons and deposition of the degraded myelin basic
protein. The data suggest that LIF signals survival in oligodendrocytes
after SCI, prevents the secondary wave of demyelination, and thereby
reduces inhibitory myelin deposits.
Item Details
Item Type: | Refereed Article |
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Keywords: | cIAP2, Demyelination, Leukemia inhibitory factor |
Research Division: | Medical and Health Sciences |
Research Group: | Neurosciences |
Research Field: | Neurosciences not elsewhere classified |
Objective Division: | Health |
Objective Group: | Clinical Health (Organs, Diseases and Abnormal Conditions) |
Objective Field: | Nervous System and Disorders |
Author: | Small, DH (Professor David Small) |
ID Code: | 58534 |
Year Published: | 2006 |
Web of Science® Times Cited: | 46 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2009-10-13 |
Last Modified: | 2009-10-13 |
Downloads: | 0 |
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