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Dynamic computer simulations of electrophoresis: Three decades of active research

Citation

Thormann, W and Caslavska, J and Breadmore, MC and Mosher, RA, Dynamic computer simulations of electrophoresis: Three decades of active research, Electrophoresis, 30, (Supplement 1) pp. S16-S26. ISSN 0173-0835 (2009) [Refereed Article]


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Copyright Statement

The definitive published version is available online at: http://interscience.wiley.com

Official URL: http://interscience.wiley.com

DOI: doi:10.1002/elps.200900058

Abstract

Dynamic models for electrophoresis are based upon model equations derived from the transport concepts in solution together with user-inputted conditions. They are able to predict theoretically the movement of ions and are as such the most versatile tool to explore the fundamentals of electrokinetic separations. Since its inception three decades ago, the state of dynamic computer simulation software and its use has progressed significantly and Electrophoresis played a pivotal role in that endeavor as a large proportion of the fundamental and application papers were published in this periodical. Software is available that simulates all basic electrophoretic systems, including moving boundary electrophoresis, zone electrophoresis, ITP, IEF and EKC, and their combinations under almost exactly the same conditions used in the laboratory. This has been employed to show the detailed mechanisms of many of the fundamental phenomena that occur in electrophoretic separations. Dynamic electrophoretic simulations are relevant for separations on any scale and instrumental format, including free-fluid preparative, gel, capillary and chip electrophoresis. This review includes a historical overview, a survey of current simulators, simulation examples and a discussion of the applications and achievements of dynamic simulation.

Item Details

Item Type:Refereed Article
Keywords:Computer simulation • EKC • IEF • ITP • Zone electrophoresis
Research Division:Chemical Sciences
Research Group:Analytical Chemistry
Research Field:Separation Science
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Chemical Sciences
Author:Breadmore, MC (Professor Michael Breadmore)
ID Code:58452
Year Published:2009
Funding Support:Australian Research Council (DP0984745)
Web of Science® Times Cited:30
Deposited By:Austn Centre for Research in Separation Science
Deposited On:2009-10-07
Last Modified:2010-04-08
Downloads:4 View Download Statistics

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