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Dynamic computer simulations of electrophoresis: Three decades of active research
Citation
Thormann, W and Caslavska, J and Breadmore, MC and Mosher, RA, Dynamic computer simulations of electrophoresis: Three decades of active research, Electrophoresis, 30, (Supplement 1) pp. S16-S26. ISSN 0173-0835 (2009) [Refereed Article]
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Copyright Statement
The definitive published version is available online at: http://interscience.wiley.com
Official URL: http://interscience.wiley.com
DOI: doi:10.1002/elps.200900058
Abstract
Dynamic models for electrophoresis are based upon model equations derived from the transport concepts in solution together with user-inputted conditions. They are able to predict theoretically the movement of ions and are as such the most versatile tool to explore the fundamentals of electrokinetic separations. Since its inception three decades ago, the state of dynamic computer simulation software and its use has progressed significantly and Electrophoresis played a pivotal role in that endeavor as a large proportion of the fundamental and application papers were published in this periodical. Software is available that simulates all basic electrophoretic systems, including moving boundary electrophoresis, zone electrophoresis, ITP, IEF and EKC, and their combinations under almost exactly the same conditions used in the laboratory. This has been employed to show the detailed mechanisms of many of the fundamental phenomena that occur in electrophoretic separations. Dynamic electrophoretic simulations are relevant for separations on any scale and instrumental format, including free-fluid preparative, gel, capillary and chip electrophoresis. This review includes a historical overview, a survey of current simulators, simulation examples and a discussion of the applications and achievements of dynamic simulation.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | Computer simulation • EKC • IEF • ITP • Zone electrophoresis |
| Research Division: | Chemical Sciences |
| Research Group: | Analytical chemistry |
| Research Field: | Separation science |
| Objective Division: | Expanding Knowledge |
| Objective Group: | Expanding knowledge |
| Objective Field: | Expanding knowledge in the chemical sciences |
| UTAS Author: | Breadmore, MC (Professor Michael Breadmore) |
| ID Code: | 58452 |
| Year Published: | 2009 |
| Funding Support: | Australian Research Council (DP0984745) |
| Web of Science® Times Cited: | 41 |
| Deposited By: | Austn Centre for Research in Separation Science |
| Deposited On: | 2009-10-07 |
| Last Modified: | 2010-04-08 |
| Downloads: | 4 View Download Statistics |
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